Inhibition of acetylcholinesterase activity by essential oils of Mentha species

被引：96

作者：

Miyazawa, M ^{[1
]}

Watanabe, H

Umemoto, K

Kameoka, H

机构：

[1] Kinki Univ, Fac Sci & Engn, Dept Appl Chem, Higashiosaka, Osaka 5778502, Japan

[2] Nagoya Gakuin Univ, Chem Lab, Aichi 4801298, Japan

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 1998年 / 46卷 / 09期

关键词：

acetylcholinesterase; Mentha species; essential oils; inhibitory activity; sesquiterpene alcohol; viridiflorol; elemol;

D O I：

10.1021/jf9707041

中图分类号：

S [农业科学];

学科分类号：

09 [农学];

摘要：

Inhibition of acetylcholinesterase (AChE) activity by several species of Mentha oils was investigated. AChE activity was measured by a colorimetric method. Mentha aquatics (water mint) containing sesquiterpene alcohols showed the most effective inhibition (IC50 of 26 mu g/mL). In addition, some Mentha species such as M. aquatics (Akasaka-hakka II), M. gentilis (Fukuyama-hakka), M. gentilis (Akita-hakka), and M, arvensis (Nihon-hakka) showed potent inhibitory activity, and their IC50 values were 28-32 mu g/mL. Viridiflorol and elemol showed the most potent inhibition in terpenoids as the main components of Mentha oils. But none of them showed stronger inhibitory activity than essential oils.

引用

页码：3431 / 3434

页数：4

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