Osmotic therapy - Fact and fiction

被引：110

作者：

Diringer, MN

Zazulia, AR

机构：

[1] Washington Univ, Sch Med, Dept Neurol, Neurol Neurosurg Intens Care Unit, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Neurol, Ctr Stroke Res, St Louis, MO 63110 USA

来源：

NEUROCRITICAL CARE | 2004年 / 1卷 / 02期

关键词：

mannitol; hypertonic saline; head injury; ischemic stroke; intracranial pressure;

D O I：

10.1385/NCC:1:2:219

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

This review examines the available data on the use of osmotic agents in patients with head injury and ischemic stroke, summarizes the physiological effects of osmotic agents, and presents the leading hypotheses regarding the mechanism by which they reduce ICP. Finally, it addresses the validity of the following commonly held beliefs: mannitol accumulates in injured brain; mannitol shrinks only normal brain and can increase midline shift; osmolality can be used to monitor mannitol administration; mannitol should be not be administered if osmolality is >320 mOsm; and hypertonic saline is equally effective as mannitol.

引用

页码：219 / 233

页数：15

共 114 条

[1] GUIDELINES FOR THE MANAGEMENT OF PATIENTS WITH ACUTE ISCHEMIC STROKE - A STATEMENT FOR HEALTH-CARE PROFESSIONALS FROM A SPECIAL WRITING GROUP OF THE STROKE-COUNCIL, AMERICAN-HEART-ASSOCIATION [J].