3-epicabraleabydroxylactone and other triterpenoids from camellia oil and their inhibitory effects on Epstein-Barr virus activation

被引：56

作者：

Akihisa, T

Tokuda, H

Ukiya, M

Suzuki, T

Enjo, F

Koike, K

Nikaido, T

Nishino, H

机构：

[1] Nihon Univ, Coll Sci & Technol, Chiyoda Ku, Tokyo 1018308, Japan

[2] Kyoto Prefectural Univ Med, Dept Biochem, Kamigyo Ku, Kyoto 6020841, Japan

[3] Oshima Tsubaki Co, Minato Ku, Tokyo 1050022, Japan

[4] Toho Univ, Sch Pharmaceut Sci, Chiba 2748510, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2004年 / 52卷 / 01期

关键词：

Camellia japonica; 3-epicabraleahydroxylactone; antitumor promoter; triterpenoids; Epstein-Barr virus early antigen;

D O I：

10.1248/cpb.52.153

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The structure of a triterpenoid isolated from the nonsaponifiable lipid (NSL) of the seed oil of the camellia (Camellia japonica L.; Theaccae) was established to be (20S)-3beta-hydroxy-25,26,27-trisnordammaran-24,20-olide (1; 3-epicabraleahydroxylactone) on the basis of spectroscopic and chemical methods. Six other triterpenoids isolated from the NSL were identified as 3-epicabraleadiol (2), ocotillol II (3), ocotillol I (4), dammarenediol II (5), (20R)-taraxastane-3beta,20-diol (6), and lupane-3beta,20-diol (7). Upon evaluation of the seven triterpenoids (1-7) with respect to their inhibitory effects on the induction of Epstein-Barr virus early antigen (EBV-EA) by 12-O-tetradecanoviphorbol-13-acetate (TPA) in Raji cells, three compounds (5-7) showed potent inhibitory effects against EBV-EA induction (IC50 values of 277-420 mol ratio/32 pmol TPA).

引用

页码：153 / 156

页数：4

共 21 条

[1] Camelliols A-C, three novel incompletely cyclized triterpene alcohols from sasanqua oil (Camellia sasanqua) [J].