Infection of immunocompromised patients by avian H9N2 influenza A virus

被引:112
作者
Cheng, Vincent C. C. [1 ]
Chan, Jasper F. W. [1 ]
Wen, X. [1 ,2 ]
Wu, W. L. [1 ,2 ]
Que, T. L. [4 ]
Chen, H. [1 ,2 ,3 ]
Chan, K. H. [1 ]
Yuen, K. Y. [1 ,2 ,3 ]
机构
[1] Queen Mary Hosp, Dept Microbiol, Pokfulam, Hong Kong, Peoples R China
[2] Univ Hong Kong, State Key Lab Emerging Infect Dis, Hong Kong, Hong Kong, Peoples R China
[3] Univ Hong Kong, Res Ctr Infect & Immunol, Hong Kong, Hong Kong, Peoples R China
[4] Tuen Mun Hosp, Dept Pathol, Hong Kong, Hong Kong, Peoples R China
关键词
Avian influenza A H9N2; Bone marrow transplantation; Immunocompromised host; SOUTHERN CHINA; HONG-KONG; H5N1; POULTRY; TRANSMISSION; EVOLUTION;
D O I
10.1016/j.jinf.2011.02.007
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Avian influenza A (H9N2) virus is transmitted sporadically from avian species to human causing mild diseases in immunocompetent person. We report two cases of human infection in immunocompromised patients in Hong Kong between 2008 and 2009. One patient had uneventful recovery with viral shedding at day 10 after symptom onset despite her underlying acute lymphoblastic leukaemia. The other patient with post-bone marrow transplant chronic graft-versus-host disease and bronhioltis obliterans went into respiratory failure. Genetic analysis revealed that these cases were caused by different genetic variants which are circulating in poultry in this region. Review of literature identified another 9 human cases reported in Southern China since 1988. It is possible that human infection with H9N2 is more common than what has been recognized. Continuous surveillance of H9N2 influenza virus infection in human is warranted. (C) 2011 The British Infection Society. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:394 / 399
页数:6
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