A picture of Mitf in melanoma immortality

被引：54

作者：

Goding, C. R. ^{[1
]}

机构：

[1] Univ Oxford, Ludwig Inst Canc Res, Nuffield Dept Clin Med, Oxford OX3 7DQ, England

来源：

ONCOGENE | 2011年 / 30卷 / 20期

关键词：

PROLIFERATION; SENESCENCE; CELLS;

D O I：

10.1038/onc.2010.641

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Mitf gene has a key role in melanocytes and melanoma by regulating cell cycle progression, survival and differentiation. Two papers in this issue of Oncogene (Cheli et al., 2011; Strub et al., 2011) reveal that low-Mitf cells can initiate tumors with high efficiency, and that Mitf blocks senescence by regulating genes implicated in S-phase progression and mitosis. Oncogene (2011) 30, 2304-2306; doi: 10.1038/onc.2010.641; published online 31 January 2011

引用

页码：2304 / 2306

页数：3

共 10 条

[1] The discovery of the microphthalmia locus and its gene, Mitf [J].

Arnheiter, Heinz .

PIGMENT CELL & MELANOMA RESEARCH, 2010, 23 (06) :729-735

[2] How to make a melanoma: what do we know of the primary clonal events? [J].

Bennett, Dorothy C. .

PIGMENT CELL & MELANOMA RESEARCH, 2008, 21 (01) :27-38

[3] Mitf regulation of Dia1 controls melanoma proliferation and invasiveness [J].

Carreira, Suzanne ;

Goodall, Jane ;

Denat, Laurence ;

Rodriguez, Mercedes ;

Nuciforo, Paolo ;

Hoek, Keith S. ;

Testori, Alessandro ;

Larue, Lionel ;

Goding, Colin R. .

GENES & DEVELOPMENT, 2006, 20 (24) :3426-3439

[4]

Cheli Y, 2011, ONCOGENE, V30, P2307, DOI 10.1038/onc.2010.598

[5] Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma [J].

Garraway, LA ;

Widlund, HR ;

Rubin, MA ;

Getz, G ;

Berger, AJ ;

Ramaswamy, S ;

Beroukhim, R ;

Milner, DA ;

Granter, SR ;

Du, JY ;

Lee, C ;

Wagner, SN ;

Li, C ;

Golub, TR ;

Rimm, DL ;

Meyerson, ML ;

Fisher, DE ;

Sellers, WR .

NATURE, 2005, 436 (7047) :117-122

[6] Microphthalmia-Associated Transcription Factor Controls the DNA Damage Response and a Lineage-Specific Senescence Program in Melanomas [J].

Giuliano, Sandy ;

Cheli, Yann ;

Ohanna, Mickael ;

Bonet, Caroline ;

Beuret, Laurent ;

Bille, Karine ;

Loubat, Agnes ;

Hofman, Veronique ;

Hofman, Paul ;

Ponzio, Gilles ;

Bahadoran, Philippe ;

Ballotti, Robert ;

Bertolotto, Corine .

CANCER RESEARCH, 2010, 70 (09) :3813-3822

[7] Cancer stem cells versus phenotype-switching in melanoma [J].

Hoek, Keith S. ;

Goding, Colin R. .

PIGMENT CELL & MELANOMA RESEARCH, 2010, 23 (06) :746-759

[8] A Temporarily Distinct Subpopulation of Slow-Cycling Melanoma Cells Is Required for Continuous Tumor Growth [J].

Roesch, Alexander ;

Fukunaga-Kalabis, Mizuho ;

Schmidt, Elizabeth C. ;

Zabierowski, Susan E. ;

Brafford, Patricia A. ;

Vultur, Adina ;

Basu, Devraj ;

Gimotty, Phyllis ;

Vogt, Thomas ;

Herlyn, Meenhard .

CELL, 2010, 141 (04) :583-594

[9] Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma [J].

Strub, T. ;

Giuliano, S. ;

Ye, T. ;

Bonet, C. ;

Keime, C. ;

Kobi, D. ;

Le Gras, S. ;

Cormont, M. ;

Ballotti, R. ;

Bertolotto, C. ;

Davidson, I. .

ONCOGENE, 2011, 30 (20) :2319-2332

[10] Tbx2 is overexpressed and plays an important role in maintaining proliferation and suppression of senescence in melanomas [J].

Vance, KW ;

Carreira, S ;

Brosch, G ;

Goding, CR .

CANCER RESEARCH, 2005, 65 (06) :2260-2268

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