Role of cannabinoid receptors in memory storage

被引:94
作者
Hampson, RE [1 ]
Deadwyler, SA
机构
[1] Wake Forest Univ, Sch Med, Dept Physiol & Pharmacol, Winston Salem, NC 27157 USA
[2] Wake Forest Univ, Sch Med, Ctr Neurobiol Invest Drug Abuse, Winston Salem, NC 27157 USA
关键词
D O I
10.1006/nbdi.1998.0223
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Studies have shown that Delta(9)-tetrahydrocannabinol, the principal psychoactive ingredient in marijuana, produces memory deficits similar to those produced by neurochemical lesions of the hippocampus. Such lesions impair performance in short-term spatial memory tasks learned prior to the lesion. Animals trained in the behavioral task following the lesion can still perform the task, but learn a different behavioral strategy. Cannabinoid agonists impair behavioral performance in a delay-dependent manner similar to that produced by lesions, but also shift the behavioral response strategy. A possible role for cannabinoid receptors and endogenous cannabinoids may thus be to regulate the storage (i.e., encoding) of information, as well as the means by which that information is retrieved, (C) 1998 Academic Press.
引用
收藏
页码:474 / 482
页数:9
相关论文
共 72 条
[1]   THE EFFECTS OF HIPPOCAMPAL-LESIONS UPON SPATIAL AND NONSPATIAL TESTS OF WORKING MEMORY [J].
AGGLETON, JP ;
HUNT, PR ;
RAWLINS, JNP .
BEHAVIOURAL BRAIN RESEARCH, 1986, 19 (02) :133-146
[2]   THE 3-DIMENSIONAL ORGANIZATION OF THE HIPPOCAMPAL-FORMATION - A REVIEW OF ANATOMICAL DATA [J].
AMARAL, DG ;
WITTER, MP .
NEUROSCIENCE, 1989, 31 (03) :571-591
[3]   HIPPOCAMPECTOMIZED MONKEYS CAN REMEMBER ONE PLACE BUT NOT 2 [J].
ANGELI, SJ ;
MURRAY, EA ;
MISHKIN, M .
NEUROPSYCHOLOGIA, 1993, 31 (10) :1021-1030
[4]   CANNABINOID RECEPTORS AND MODULATION OF CYCLIC-AMP ACCUMULATION IN THE RAT-BRAIN [J].
BIDAUTRUSSELL, M ;
DEVANE, WA ;
HOWLETT, AC .
JOURNAL OF NEUROCHEMISTRY, 1990, 55 (01) :21-26
[5]   CRITICAL ROLE OF THE PARAHIPPOCAMPAL REGION FOR PAIRED-ASSOCIATE LEARNING IN RATS [J].
BUNSEY, M ;
EICHENBAUM, H .
BEHAVIORAL NEUROSCIENCE, 1993, 107 (05) :740-747
[6]  
CAMPBELL KA, 1986, J PHARMACOL EXP THER, V239, P936
[7]  
CAMPBELL KA, 1986, J PHARMACOL EXP THER, V239, P941
[8]  
CHAIT LD, 1992, MARIJUANA CANNABINOI, P387
[9]  
CHO YH, 1993, J NEUROSCI, V13, P1759
[10]   PREVENTION BY THE CANNABINOID ANTAGONIST, SR141716A, OF CANNABINOID-MEDIATED BLOCKADE OF LONG-TERM POTENTIATION IN THE RAT HIPPOCAMPAL SLICE [J].
COLLINS, DR ;
PERTWEE, RG ;
DAVIES, SN .
BRITISH JOURNAL OF PHARMACOLOGY, 1995, 115 (06) :869-870