Susceptibility of Chinese rhesus monkeys to SIV infection

被引：45

作者：

Burdo, TH ^{[1
]}

Marcondes, MCG

Lanigan, CMS

Penedo, MCT

Fox, HS

机构：

[1] Scripps Res Inst, Dept Neuropharmacol, La Jolla, CA 92037 USA

[2] Scripps Res Inst, DNA Array Core Facil, La Jolla, CA 92037 USA

[3] Univ Calif Davis, Vet Genet Lab, Davis, CA 95616 USA

来源：

AIDS | 2005年 / 19卷 / 15期

关键词：

D O I：

10.1097/01.aids.0000186823.76230.33

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The use of China-derived monkeys in AIDS research has been limited by reports of reduced susceptibility to SIV. We performed a serial passage of SIV in Chinese macaques, which resulted in a viral stock capable of inducing simian AIDS and high levels of replication in these animals. Similar to HIV in humans, SIV pathogenesis in non-human primates is not limited by geographical origin. Chinese macaques are useful in pathogenesis, vaccine, and therapeutic studies in AIDS.

引用

页码：1704 / 1706

页数：3

共 17 条

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