Training-induced brain structure changes in the elderly

被引：460

作者：

Boyke, Janina ^{[1
]}

Driemeyer, Joenna ^{[1
]}

Gaser, Christian ^{[2
]}

Buechel, Christian ^{[1
]}

May, Arne ^{[1
]}

机构：

[1] Univ Hamburg, Dept Syst Neurosci, D-22046 Hamburg, Germany

[2] Univ Jena, Dept Psychiat, D-07740 Jena, Germany

来源：

JOURNAL OF NEUROSCIENCE | 2008年 / 28卷 / 28期

关键词：

age; brain; plasticity; learning; voxel-based morphometry; hippocampus;

D O I：

10.1523/JNEUROSCI.0742-08.2008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

It has been suggested that learning is associated with a transient and highly selective increase in brain gray matter in healthy young volunteers. It is not clear whether and to what extent the aging brain is still able to exhibit such structural plasticity. We built on our original study, now focusing on healthy senior citizens. We observed that elderly persons were able to learn three-ball cascade juggling, but with less proficiency compared with 20-year-old adolescents. Similar to the young group, gray-matter changes in the older brain related to skill acquisition were observed in area hMT/V5 (middle temporal area of the visual cortex). In addition, elderly volunteers who learned to juggle showed transient increases in gray matter in the hippocampus on the left side and in the nucleus accumbens bilaterally.

引用

页码：7031 / 7035

页数：5

共 36 条

[11] Phantom limb pain: a case of maladaptive CNS plasticity? [J].

Flor, Herta ;

Nikolajsen, Lone ;

Jensen, Troels Staehelin .

NATURE REVIEWS NEUROSCIENCE, 2006, 7 (11) :873-881

[12] Neurogenesis in the adult brain [J].

Gage, FH .

JOURNAL OF NEUROSCIENCE, 2002, 22 (03) :612-613

[13]

Gaser C, 2003, J NEUROSCI, V23, P9240

[14] Anatomical correlates of learning novel speech sounds [J].

Golestani, N ;

Paus, T ;

Zatorre, RJ .

NEURON, 2002, 35 (05) :997-1010

[15] A voxel-based morphometric study of ageing in 465 normal adult human brains [J].

Good, CD ;

Johnsrude, IS ;

Ashburner, J ;

Henson, RNA ;

Friston, KJ ;

Frackowiak, RSJ .

NEUROIMAGE, 2001, 14 (01) :21-36

[16] Cerebral asymmetry and the effects of sex and handedness on brain structure: A voxel-based morphometric analysis of 465 normal adult human brains [J].

Good, CD ;

Johnsrude, I ;

Ashburner, J ;

Henson, RNA ;

Friston, KJ ;

Frackowiak, RSJ .

NEUROIMAGE, 2001, 14 (03) :685-700

[17] The effect of aging on adaptive eye-hand coordination [J].

Guan, JH ;

Wade, MG .

JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES, 2000, 55 (03) :P151-P162

[18] MORPHOMETRY OF THE HUMAN CORTEX CEREBRI AND CORPUS STRIATUM DURING AGING [J].

HAUG, H ;

EGGERS, R .

NEUROBIOLOGY OF AGING, 1991, 12 (04) :336-338

[19] Insights into the ageing mind: A view from cognitive neuroscience [J].

Hedden, T ;

Gabrieli, JDE .

NATURE REVIEWS NEUROSCIENCE, 2004, 5 (02) :87-U12

[20] The role of nucleus accumbens dopamine in motivated behavior: a unifying interpretation with special reference to reward-seeking [J].

Ikemoto, S ;

Panksepp, J .

BRAIN RESEARCH REVIEWS, 1999, 31 (01) :6-41

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