Activation of lateral habenula inputs to the ventral midbrain promotes behavioral avoidance

被引：410

作者：

Stamatakis, Alice M. ^{[1
]}

Stuber, Garret D. ^{[1
,2
,3
]}

机构：

[1] UNC, UNC Neurobiol Curriculum, UNC Neurosci Ctr, Chapel Hill, NC 27515 USA

[2] UNC, UNC Neurosci Ctr, Dept Psychiat, Chapel Hill, NC USA

[3] UNC, UNC Neurosci Ctr, Dept Cellular & Mol Physiol, Chapel Hill, NC USA

来源：

NATURE NEUROSCIENCE | 2012年 / 15卷 / 08期

关键词：

DOPAMINE NEURONS; NUCLEUS-ACCUMBENS; TEGMENTAL AREA; GABA NEURONS; REWARD; VTA; PREDICTION; AVERSION; STIMULI;

D O I：

10.1038/nn.3145

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Lateral habenula (LHb) projections to the ventral midbrain, including the rostromedial tegmental nucleus (RMTg), convey negative reward-related information, but the behavioral ramifications of selective activation of this pathway remain unexplored. We found that exposure to aversive stimuli in mice increased LHb excitatory drive onto RMTg neurons. Furthermore, optogenetic activation of this pathway promoted active, passive and conditioned behavioral avoidance. Thus, activity of LHb efferents to the midbrain is aversive but can also serve to negatively reinforce behavioral responding.

引用

页码：1105 / +

页数：5

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