Cystatin C as a risk factor for Alzheimer disease

被引：50

作者：

Cathcart, HM

Huang, R

Lanham, IS

Corder, EH

Poduslo, SE

机构：

[1] Med Coll Georgia, IMMAG, Augusta, GA 30912 USA

[2] Med Coll Georgia, Dept Neurol, Augusta, GA 30912 USA

[3] Vet Affairs Med Ctr, Augusta, GA USA

[4] Duke Univ, Ctr Demog Studies, Durham, NC 27706 USA

来源：

NEUROLOGY | 2005年 / 64卷 / 04期

关键词：

D O I：

10.1212/01.WNL.0000151980.42337.44

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cystatin C, a protease inhibitor with widespread distribution, is upregulated in response to injury. Levels are elevated in the brains of patients with Alzheimer disease ( AD). We compared frequencies for the CST 3 exon 1 polymorphism in patients with AD and controls. A proportional odds model indicated that the CST 3 A and APOE4 combination carried a high risk: a 14-fold elevation for men and 16-fold for women. These risks apply to risk at ages older than 64 years and to a shift in onset to ages younger than 65 years.

引用

页码：755 / 757

页数：3

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