DisProt: a database of protein disorder

被引:177
作者
Vucetic, S
Obradovic, Z
Vacic, V
Radivojac, P
Peng, K
Iakoucheva, LM
Cortese, MS
Lawson, JD
Brown, CJ
Sikes, JG
Newton, CD
Dunker, AK [1 ]
机构
[1] Indiana Univ, Sch Med, Ctr Computat Biol & Bioinformat, Indianapolis, IN 46202 USA
[2] Temple Univ, Ctr Informat Sci & Technol, Philadelphia, PA 19122 USA
[3] Rockefeller Univ, Lab Stat Genet, New York, NY 10021 USA
[4] Concurrent Pharmaceut, Ft Washington, PA 19034 USA
[5] Univ Idaho, Dept Biol Sci, Moscow, ID 83844 USA
[6] Washington State Univ, Sch Mol Biosci, Pullman, WA 99164 USA
关键词
D O I
10.1093/bioinformatics/bth476
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The Database of Protein Disorder (DisProt) is a curated database that provides structure and function information about proteins that lack a fixed three-dimensional (3D) structure under putatively native conditions, either in their entirety or in part. Starting from the central premise that intrinsic disorder is an important structural class of protein and in order to meet the increasing interest thereof, DisProt is aimed at becoming a central repository of disorder-related information. For each disordered protein, the database includes the name of the protein, various aliases, accession codes, amino acid sequence, location of the disordered region(s), and methods used for structural (disorder) characterization. If applicable, most entries also list the biological function(s) of each disordered region, how each region of disorder is used for function, as well as provide links to PubMed abstracts and major protein databases.
引用
收藏
页码:137 / 140
页数:4
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