Protein aspartate phosphatases control the output of two-component signal transduction systems

被引:72
作者
Perego, M
Hoch, JA
机构
[1] Dept. of Molec. and Exp. Medicine, Division of Cellular Biology, Scripps Research Institute, San Diego, CA 92037
关键词
D O I
10.1016/0168-9525(96)81420-X
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Phosphorylation or dephosphorylation of an aspartate regulates the output activity of the response regulator or two-component signaling systems. Signal input in these systems is dependent on signal-transducing kinases, which can respond to a variety of signal ligands and, in some cases, to small phosphorylated metabolic intermediates. The kinase component of many two-component signaling systems also displays a response regulator-phosphate phosphatase activity that inactivates the response regulator in response to signals. Newly discovered kinase-independent phosphatases allow additional signals to influence the extent of response-regulator phosphorylation. Such phosphatases are prevalent in signal transduction system controlling complex precesses, such as the initiation of development in microorganisms.
引用
收藏
页码:97 / 101
页数:5
相关论文
共 29 条
[1]  
AIBA H, 1989, J BIOL CHEM, V264, P1
[2]  
Amsler CD., 1995, 2 COMPONENT SIGNAL T, P89
[3]   INITIATION OF SPORULATION IN BACILLUS-SUBTILIS IS CONTROLLED BY A MULTICOMPONENT PHOSPHORELAY [J].
BURBULYS, D ;
TRACH, KA ;
HOCH, JA .
CELL, 1991, 64 (03) :545-552
[4]   ARABIDOPSIS ETHYLENE-RESPONSE GENE ETR1 - SIMILARITY OF PRODUCT TO 2-COMPONENT REGULATORS [J].
CHANG, C ;
KWOK, SF ;
BLEECKER, AB ;
MEYEROWITZ, EM .
SCIENCE, 1993, 262 (5133) :539-544
[5]   GENETIC COMPETENCE IN BACILLUS-SUBTILIS [J].
DUBNAU, D .
MICROBIOLOGICAL REVIEWS, 1991, 55 (03) :395-424
[6]   HISTIDINE PHOSPHORYLATION AND PHOSPHORYL GROUP TRANSFER IN BACTERIAL CHEMOTAXIS [J].
HESS, JF ;
BOURRET, RB ;
SIMON, MI .
NATURE, 1988, 336 (6195) :139-143
[7]  
Hoch J.A. T.J. Silhavy., 1995, 2 COMPONENT SIGNAL T
[8]   ON TARGET WITH A NEW MECHANISM FOR THE REGULATION OF PROTEIN-PHOSPHORYLATION [J].
HUBBARD, MJ ;
COHEN, P .
TRENDS IN BIOCHEMICAL SCIENCES, 1993, 18 (05) :172-177
[9]   PHOSPHORYLATION AND DEPHOSPHORYLATION OF A BACTERIAL TRANSCRIPTIONAL ACTIVATOR BY A TRANSMEMBRANE RECEPTOR [J].
IGO, MM ;
NINFA, AJ ;
STOCK, JB ;
SILHAVY, TJ .
GENES & DEVELOPMENT, 1989, 3 (11) :1725-1734
[10]  
KAMBEROV ES, 1994, J BIOL CHEM, V269, P28294