Involvement of vesicular trafficking system in membrane targeting of the progeny influenza virus genome

被引：26

作者：

Jo, Shuichi ^{[2
]}

Kawaguchi, Atsushi ^{[1
,2
]}

Takizawa, Naoki ^{[3
]}

Morikawa, Yuko ^{[1
]}

Momose, Fumitaka ^{[1
]}

Nagata, Kyosuke ^{[2
]}

机构：

[1] Kitasato Univ, Kitasato Inst Life Sci, Minato Ku, Tokyo 1088641, Japan

[2] Univ Tsukuba, Dept Infect Biol, Grad Sch Comprehens Human Sci, Tsukuba, Ibaraki 3058575, Japan

[3] Nagasaki Univ, Grad Sch Biomed Sci, Nagasaki 8528521, Japan

来源：

MICROBES AND INFECTION | 2010年 / 12卷 / 12-13期

关键词：

Influenza virus; Vesicular trafficking; Ribonucleoprotein; Fluorescence in situ hybridization; BASOLATERAL LOCALIZATION SIGNAL; A VIRUS; NUCLEAR EXPORT; RIBONUCLEOPROTEIN COMPLEXES; PROTEIN; NUCLEOPROTEIN; HEMAGGLUTININ; REPLICATION; M1; GLYCOPROTEINS;

D O I：

10.1016/j.micinf.2010.06.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The genome of influenza type A virus consists of single-stranded RNAs of negative polarity Progeny viral RNA (vRNA) replicated in the nucleus is nuclear-exported, and finally transported to the budding site beneath the plasma membrane However, the precise process of the membrane targeting of vRNA is unclear although viral proteins and cytoskeleton are thought to play roles Here we have visualized the translocation process of progeny vRNA using fluorescence in situ hybridization method Our results provide an evidence of the Involvement of vesicular trafficking in membrane targeting of progeny vRNA independent of that of viral membrane proteins (C) 2010 Institut Pasteur Published by Elsevier Masson SAS All rights reserved

引用

页码：1079 / 1084

页数：6

共 22 条

[1] Influenza virus assembly: Effect of influenza virus glycoproteins on the membrane association of M1 protein [J].

Ali, A ;

Avalos, RT ;

Ponimaskin, E ;

Nayak, DP .

JOURNAL OF VIROLOGY, 2000, 74 (18) :8709-8719

[2] Association of influenza virus NP and M1 proteins with cellular cytoskeletal elements in influenza virus-infected cells [J].

Avalos, RT ;

Yu, Z ;

Nayak, DP .

JOURNAL OF VIROLOGY, 1997, 71 (04) :2947-2958

[3] Influenza A virus hemagglutinin containing basolateral localization signal does not alter the apical budding of a recombinant influenza A virus in polarized MDCK cells [J].

Barman, S ;

Adhikary, L ;

Kawaoka, Y ;

Nayak, DP .

VIROLOGY, 2003, 305 (01) :138-152

[4] Lipid raft-dependent targeting of the influenza A virus nucleoprotein to the apical plasma membrane [J].

Carrasco, M ;

Amorim, MJ ;

Digard, P .

TRAFFIC, 2004, 5 (12) :979-992

[5] Modulation of nuclear localization of the influenza virus nucleoprotein through interaction with actin filaments [J].

Digard, P ;

Elton, D ;

Bishop, K ;

Medcalf, E ;

Weeds, A ;

Pope, B .

JOURNAL OF VIROLOGY, 1999, 73 (03) :2222-2231

[6] Golgi-disturbing agents [J].

Dinter, A ;

Berger, EG .

HISTOCHEMISTRY AND CELL BIOLOGY, 1998, 109 (5-6) :571-590

[7] Interaction of the influenza virus nucleoprotein with the cellular CRM1-mediated nuclear export pathway [J].

Elton, D ;

Simpson-Holley, M ;

Archer, K ;

Medcalf, L ;

Hallam, R ;

McCauley, J ;

Digard, P .

JOURNAL OF VIROLOGY, 2001, 75 (01) :408-419

[8] Effect of influenza virus matrix protein and viral RNA on ribonucleoprotein formation and nuclear export [J].

Huang, XY ;

Liu, T ;

Muller, J ;

Levandowski, RA ;

Ye, ZP .

VIROLOGY, 2001, 287 (02) :405-416

[9] THE INFLUENZA-VIRUS HEMAGGLUTININ CYTOPLASMIC TAIL IS NOT ESSENTIAL FOR VIRUS ASSEMBLY OR INFECTIVITY [J].

JIN, H ;

LESER, GP ;

LAMB, RA .

EMBO JOURNAL, 1994, 13 (22) :5504-5515

[10] INFLUENZA TYPE-A VIRUS NEURAMINIDASE DOES NOT PLAY A ROLE IN VIRAL ENTRY, REPLICATION, ASSEMBLY, OR BUDDING [J].

LIU, CG ;

EICHELBERGER, MC ;

COMPANS, RW ;

AIR, GM .

JOURNAL OF VIROLOGY, 1995, 69 (02) :1099-1106

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