Diastereoselective synthesis of α-substituted β-amidophosphonates

被引：23

作者：

Castelot-Deliencourt, G

Pannecoucke, X

Quirion, JC

机构：

[1] INSA, LHO, UPRESA CNRS 6014, IRCOF, F-76821 Mt St Aignan, France

[2] Univ Rouen, F-76821 Mt St Aignan, France

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 06期

关键词：

asymmetric synthesis; phosphonic acids and derivatives; Michael addition;

D O I：

10.1016/S0040-4039(00)02145-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and general asymmetric synthesis of beta -amidophosphonates is described. The method involves the highly selective addition (up to 95% d.e.) of diethyl phosphite to various chiral alpha,beta -unsaturated carboxylic amides derived from chiral aminoalcohols. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：1025 / 1028

页数：4

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