Caution in generalizing known genetic risk markers for breast cancer across all ethnic/racial populations

被引：17

作者：

Chen, Fang ^{[1
]}

Stram, Daniel O. ^{[1
]}

Le Marchand, Loic ^{[2
]}

Monroe, Kristine R. ^{[1
]}

Kolonel, Laurence N. ^{[2
]}

Henderson, Brian E. ^{[1
]}

Haiman, Christopher A. ^{[1
]}

机构：

[1] Univ So Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 90033 USA

[2] Univ Hawaii, Canc Res Ctr Hawaii, Program Epidemiol, Honolulu, HI 96813 USA

来源：

EUROPEAN JOURNAL OF HUMAN GENETICS | 2011年 / 19卷 / 02期

关键词：

breast cancer; risk markers; summary score; generalizability; diverse populations; GENOME-WIDE ASSOCIATION; SUSCEPTIBILITY LOCI; CONFER SUSCEPTIBILITY; MULTIPLE POPULATIONS; AFRICAN-AMERICAN; COMMON VARIANTS; GENERALIZABILITY; MODELS;

D O I：

10.1038/ejhg.2010.185

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genome-wide association studies (GWAS) have identified common variants associated with breast cancer risk among women of European and Asian ancestries. To assess the generalizability across ethnic/racial populations of a risk score derived from genotyping 12 highly replicated breast cancer GWAS hits, we performed a case-control study (2224 cases and 2827 controls) nested in the Multiethnic Cohort (MEC) study, which was initiated in 1993-1996 and consists of subjects mainly from European-American, African-American, Native Hawaiian, Japanese and Latino populations. When viewed as a summary risk score, the total number of risk alleles carried by women was significantly associated with breast cancer risk overall (OR per allele, 1.09; 95% CI, 1.06-1.12; P=2.0 x 10(-10)) and in all populations except African-Americans, in which no significant association was observed (OR, 1.03; 95% CI, 0.98-1.08). In aggregate, the number of risk alleles is strongly associated with breast cancer risk in all populations studied except African-Americans. These results emphasize the need for large-scale association studies of multiple racial/ethnic groups for discovery and characterization of risk alleles relevant to all populations in the United States. European Journal of Human Genetics (2011) 19, 243-245; doi:10.1038/ejhg.2010.185; published online 24 November 2010 populations

引用

页码：243 / 245

页数：3

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