Application of derivative spectrophotometry for determination of coenzyme Q10 in pharmaceuticals and plasma

被引：28

作者：

Karpinska, J

Mikoluc, B

Piotrowska-Jastrzebska, J

机构：

[1] Univ Bialystok, PL-15447 Bialystok, Poland

[2] Med Acad Bialystok, Dept Pediat Propedeut, PL-15274 Bialystok, Poland

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1998年 / 17卷 / 08期

关键词：

derivative spectrophotometry; coenzyme Q(10) analysis; Savitzky-Golay algorithm;

D O I：

10.1016/S0731-7085(98)00003-X

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The use of derivative spectrophotometry is proposed in this work for determination of coenzyme Q(10) in formulations and in human plasma. The spectrophotometric procedure is simpler and less expensive than chromatographic techniques commonly used for the analysis of coenzyme. The active compound can be determined in the range 0.25-10 ppm for standard solutions and pharmaceuticals and 0.05-1.5 ppm in plasma. The proposed method was applied for coenzyme determination in real samples. The results agree well with declared value and with these obtained by HPLC. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：1345 / 1350

页数：6

共 17 条

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