Thorectandrols A and B, new cytotoxic sesterterpenes from the marine sponge Thorectandra species

被引：23

作者：

Charan, RD ^{[1
]}

McKee, TC ^{[1
]}

Boyd, MR ^{[1
]}

机构：

[1] NCI, Ctr Canc Res, Lab Drug Discovery Res & Dev, Frederick, MD 21702 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 05期

关键词：

D O I：

10.1021/np000544e

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new sesterterpenes, thorectandrol A (1) and B (2), were isolated from extracts of the marine sponge Thorectandra sp. The structures were determined by extensive NMR spectral data analysis. NOE correlations were used to define the relative stereochemistry of 1 and 2, while CD data were used to suggest their absolute stereochemistry. Both compounds 1 and 2 inhibited the growth of MALME-3M (melanoma) and MCF-7 (breast) cancer cell lines in the range 30-40 mug/mL. The known compound palauolol (3) was isolated as well and was also cytotoxic.

引用

页码：661 / 663

页数：3

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