Highly sensitive MRI chemical exchange saturation transfer agents using liposomes

被引：139

作者：

Aime, S

Delli Castelli, D

Terreno, E

机构：

[1] IFM, Dipartimento Chim, I-10125 Turin, Italy

[2] Mol Imaging Ctr, I-10125 Turin, Italy

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 34期

关键词：

imaging agents; lanthanides; liposomes; MRI; shift reagents;

D O I：

10.1002/anie.200501473

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Contrasting views: Entrapment of a paramagnetic shift reagent for water protons inside liposomes dramatically improves the sensitivity of chemical exchange saturation transfer agents. The chemical shift of the water entrapped within the liposomes, relative to bulk water, depends upon the nature and concentration of the shift reagent as well as on the permeability of the liposome membrane (see picture; SR = shift reagent, Ln = lanthanide ion). © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

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收藏

页码：5513 / 5515

页数：3

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