Hyphae and yeasts of Candida albicans differentially regulate interleukin-12 production by human blood monocytes:: Inhibitory role of C-albicans germination

被引：25

作者：

Liu, LM

Kang, KF

Takahara, M

Cooper, KD

Ghannoum, MA

机构：

[1] Case Western Reserve Univ, Dept Dermatol, Cleveland, OH 44106 USA

[2] Case Western Reserve Univ, Ctr Med Mycol, Cleveland, OH 44106 USA

[3] Univ Hosp Cleveland, Cleveland, OH 44106 USA

[4] VA Med Ctr, Cleveland, OH USA

来源：

INFECTION AND IMMUNITY | 2001年 / 69卷 / 07期

关键词：

D O I：

10.1128/IAI.69.7.4695-4697.2001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The role of Candida albicans yeast-to-hypha transition in interleukin-12 (IL-12) production by monocytes was investigated. Germinating C. albicans not only failed to induce IL-12 p70 but also suppressed IL-12 production induced by heat-killed C. albicans, Comparison of the abilities of germinating C, albicans and agerminating mutants to inhibit IL-12 production showed that germination of C. albicans plays a critical role in the inhibition of IL-12 production.

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页码：4695 / 4697

页数：3

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