The antimalarial trioxaquine DU1301 alkylates heme in malaria-infected mice

被引：30

作者：

Garah, Fatima Bousejra-El ^{[1
]}

Claparols, Catherine ^{[1
]}

Benoit-Vical, Francoise ^{[1
,2
]}

Meunier, Bernard

Robert, Anne ^{[1
]}

机构：

[1] CNRS, Chim Coordinat Lab, F-31077 Toulouse 4, France

[2] Univ Toulouse, CHU Rangueil, Serv Parasitol & Mycol, TSA 50032, F-31059 Toulouse 9, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2008年 / 52卷 / 08期

关键词：

D O I：

10.1128/AAC.00165-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The in vivo alkylation of heme by the antimalarial trioxaquine DU1301 afforded covalent heme-drug adducts that were detected in the spleens of Plasmodium sp.-infected mice. This result indicates that the alkylation capacities of trioxaquines in mammals infected with Plasmodium strains are similar to that of artemisinin, a natural antimalarial trioxane-containing drug.

引用

页码：2966 / 2969

页数：4

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