Efficient aqueous-phase Heck and Suzuki couplings of aryl bromides using tri(4,6-dimethyl-3-sulfonatophenyl)phosphine trisodium salt(TXPTS)

被引：130

作者：

Moore, LR ^{[1
]}

Shaughnessy, KH

机构：

[1] Univ Alabama, Dept Chem, Tuscaloosa, AL 35487 USA

[2] Univ Alabama, Ctr Green Mfg, Tuscaloosa, AL 35487 USA

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 02期

关键词：

D O I：

10.1021/ol0360288

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Sterically demanding, sulfonated arylphosphines TXPTS and TMAPTS have been applied to the aqueous-phase Heck and Suzuki coupling of aryl bromides. TXPTS provides good yields of Heck coupling products from aryl bromides at 80 degreesC, while both TMAPTS and TPPTS gave significantly less active catalysts. TXPTS is the first ligand to promote the aqueous-phase Heck coupling under such mild conditions. Both TXPTS and TMAPTS provide active catalysts for Suzuki couplings of aryl bromides at 50 degreesC.

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页码：225 / 228

页数：4

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