Inhibitors of acyl-CoA:cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. CI-1011: An acyl sulfamate with unique cholesterol-lowering activity in animals fed noncholesterol-supplemented diets

被引:85
作者
Lee, HT
Sliskovic, DR
Picard, JA
Roth, BD
Wierenga, W
Hicks, JL
Bousley, RF
Hamelehle, KL
Homan, R
Speyer, C
Stanfield, RL
Krause, BR
机构
[1] WARNER LAMBERT PARKE DAVIS,PARKE DAVIS PHARMACEUT RES,DEPT MED CHEM,ANN ARBOR,MI 48105
[2] WARNER LAMBERT PARKE DAVIS,PARKE DAVIS PHARMACEUT RES,DEPT RADIOCHEM,ANN ARBOR,MI 48105
[3] WARNER LAMBERT PARKE DAVIS,PARKE DAVIS PHARMACEUT RES,DEPT VASC & CARDIAC DIS,ANN ARBOR,MI 48105
关键词
D O I
10.1021/jm960674d
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
[No abstract available]
引用
收藏
页码:5031 / 5034
页数:4
相关论文
共 21 条
  • [1] AUERBACH BJ, 1995, 12 INT S DRUGS AFF L, P135
  • [2] BILLHEIMER JT, 1991, 9TH INT S ATH ROS, P94
  • [3] CHAO YS, 1986, BIOCHIM BIOPHYS ACTA, V876, P392
  • [4] APO-B METABOLISM IN FAMILIAL HYPERCHOLESTEROLEMIA - INCONSISTENCIES WITH THE LDL RECEPTOR PARADIGM
    FISHER, WR
    ZECH, LA
    STACPOOLE, PW
    [J]. ARTERIOSCLEROSIS AND THROMBOSIS, 1994, 14 (04): : 501 - 510
  • [5] EFFECT OF THE ACYL-COA-CHOLESTEROL ACYLTRANSFERASE INHIBITOR DUP-128 ON CHOLESTEROL ABSORPTION AND SERUM-CHOLESTEROL IN HUMANS
    HAINER, JW
    TERRY, JG
    CONNELL, JM
    ZYRUK, H
    JENKINS, RM
    SHAND, DL
    GILLIES, PJ
    LIVAK, KJ
    HUNT, TL
    CROUSE, JR
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 1994, 56 (01) : 65 - 74
  • [6] EFFECTS OF THE ACAT INHIBITOR CL-277,082 ON CHOLESTEROL-METABOLISM IN HUMANS
    HARRIS, WS
    DUJOVNE, CA
    VONBERGMANN, K
    NEAL, J
    AKESTER, J
    WINDSOR, SL
    GREENE, D
    LOOK, Z
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 1990, 48 (02) : 189 - 194
  • [7] EFFECT OF MEMBRANE ENVIRONMENT ON INHIBITION OF ACYL-COA-CHOLESTEROL ACYLTRANSFERASE BY A RANGE OF SYNTHETIC INHIBITORS
    HARTE, RA
    YEAMAN, SJ
    JACKSON, B
    SUCKLING, KE
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM, 1995, 1258 (03): : 241 - 250
  • [8] SYNTHESES AIDED BY HETEROCUMULENES .4. ACTION OF CHLOROSULFONYL ISOCYANATE ON HINDERED PHENOLS
    HEDAYATULLAH, M
    HUGUENY, JC
    [J]. PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 1984, 19 (02) : 167 - 172
  • [9] HOMAN R, 1995, 23 INT S DRUGS AFF L, P61
  • [10] Julian T. N., 1995, Pharmaceutical Research (New York), V12, pS318