A Rat Model of Studying Tissue-Type Plasminogen Activator Thrombolysis in Ischemic Stroke With Diabetes

被引：67

作者：

Fan, Xiang ^{[1
]}

Qiu, Jianhua ^{[1
]}

Yu, Zhanyang ^{[1
]}

Dai, Haibin ^{[1
]}

Singhal, Aneesh B. ^{[1
]}

Lo, Eng H. ^{[1
]}

Wang, Xiaoying ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Neurosci Program,Neuroprotect Res Lab, Massachusetts Gen Hosp,Dept Neurol & Radiol, Boston, MA 02115 USA

来源：

STROKE | 2012年 / 43卷 / 02期

关键词：

diabetes; rats; thrombolytics; tPA; HYPERGLYCEMIA; INHIBITOR; OCCLUSION; PREDICTS; THERAPY;

D O I：

10.1161/STROKEAHA.111.635250

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Purpose-Poststroke hyperglycemia and diabetes mellitus are associated with lower thrombolytic efficacy and an increased risk of postischemic cerebral hemorrhage. We aimed to develop a rodent model of thrombolysis in diabetic stroke that mimics the clinical situation. Method-Male 6-week Type I diabetic rats (14 weeks old) were subjected to embolic focal stroke and treated with tissue-type plasminogen activator at 1.5 hours. Reperfusion and 24-hour neurological outcomes were measured and compared with nondiabetic control rats. Results-Diabetic rats exhibited resistance to thrombolytic reperfusion, larger infarction volumes, and increased intracerebral hemorrhage. Conclusions-This animal model would be relevant to future studies investigating pathophysiological mechanisms and in developing new therapeutic approaches to enhance the efficacy of tissue-type plasminogen activator thrombolysis in stroke patients with diabetes or poststroke hyperglycemia. (Stroke. 2012;43:567-570.)

引用

收藏

页码：567 / 570

页数：4

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