Genetic diversity of multidrug-resistant Mycobacterium tuberculosis isolates and identification of 11 novel rpoB alleles in Taiwan

被引：38

作者：

Jou, R

Chen, HY

Chiang, CY

Yu, MC

Su, IJ

机构：

[1] Dept Hlth, Ctr Dis Control, Reference Lab Mycobacteriol, Taipei 115, Taiwan

[2] Taipei Med Univ, Municipal Wan Fan Hosp, Taipei, Taiwan

[3] Natl Hlth Res Inst, Div Clin Res, Tainan, Taiwan

[4] Int Union Against TB & Lung Dis, Paris, France

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2005年 / 43卷 / 03期

关键词：

D O I：

10.1128/JCM.43.3.1390-1394.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Of 162 multidrug-resistant Mycobacterium tuberculosis isolates from Taiwan, 60.5% were found to belong to the Beijing family on the basis of spoligotyping results. IS6110 restriction fragment length polymorphism fingerprinting showed genetic diversity among the multidrug-resistant isolates. Furthermore, 90.1% of the multidrug-resistant isolates had mutations in the rpoB gene, and 11 novel alleles were recognized.

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页码：1390 / 1394

页数：5

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