Variations in the vitamin D-binding protein (Gc locus) are associated with oral glucose tolerance in nondiabetic Pima Indians

被引：57

作者：

Baier, LJ ^{[1
]}

Dobberfuhl, AM ^{[1
]}

Pratley, RE ^{[1
]}

Hanson, RL ^{[1
]}

Bogardus, C ^{[1
]}

机构：

[1] NIDDKD, Clin Diabet & Nutr Sect, Phoenix Epidemiol & Clin Res Branch, NIH, Phoenix, AZ 85016 USA

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 1998年 / 83卷 / 08期

关键词：

D O I：

10.1210/jc.83.8.2993

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Electrophoretic variants of the vitamin D-binding protein (DBP) have been associated with type 2 diabetes as well as with metabolic characteristics that predispose to type 2 diabetes in several populations. The Ge gene that encodes DBP maps to chromosome 4q12, a region that has recently been found to be potentially linked to plasma glucose and insulin concentrations in Pima Indians. Therefore, the gene that encodes DBP was analyzed as a candidate gene for our linkage findings in the Pima Indians. Sequence analysis of the coding exons identified two previously described missense polymorphisms at codons 416 and 420, which are the genetic basis for the three common electrophoretic variants of DBP (Gc1f, Gc1s, and Gc2). These variants in DBP were associated with differences in oral glucose tolerance in nondiabetic Pima Indians.

引用

页码：2993 / 2996

页数：4

共 19 条

[1]

BAIER L, 1996, DIABETES S2, V45, pA30

[2] Vitamin D, glucose tolerance and insulinaemia in elderly men [J].

Baynes, KCR ;

Boucher, BJ ;

Feskens, EJM ;

Kromhout, D .

DIABETOLOGIA, 1997, 40 (03) :344-347

[3] GLUCOSE-INTOLERANCE AND IMPAIRMENT OF INSULIN-SECRETION IN RELATION TO VITAMIN-D DEFICIENCY IN EAST LONDON ASIANS [J].

BOUCHER, BJ ;

MANNAN, N ;

NOONAN, K ;

HALES, CN ;

EVANS, SJW .

DIABETOLOGIA, 1995, 38 (10) :1239-1245

[4] SEQUENCE AND ORGANIZATION OF THE HUMAN VITAMIN-D-BINDING PROTEIN GENE [J].

BRAUN, A ;

KOFLER, A ;

MORAWIETZ, S ;

CLEVE, H .

BIOCHIMICA ET BIOPHYSICA ACTA, 1993, 1216 (03) :385-394

[5] GROUP-SPECIFIC COMPONENT (GC) PROTEINS BIND VITAMIN-D AND 25-HYDROXYVITAMIN-D [J].

DAIGER, SP ;

SCHANFIELD, MS ;

CAVALLISFORZA, LL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (06) :2076-2080

[6]

HIRAI M, 1997, DIABETES, V46, pA170

[7] ON THE ROLE OF VITAMIN-D BINDING GLOBULIN IN GLUCOSE-HOMEOSTASIS - RESULTS FROM THE SAN LUIS VALLEY DIABETES STUDY [J].

IYENGAR, S ;

HAMMAN, RF ;

MARSHALL, JA ;

MAJUMDER, PP ;

FERRELL, RE .

GENETIC EPIDEMIOLOGY, 1989, 6 (06) :691-698

[8] DEMONSTRATION THAT THE VITAMIN-D METABOLITE 1,25(OH)2-VITAMIN-D3 AND NOT 24R,25(OH)2-VITAMIN-D3 IS ESSENTIAL FOR NORMAL INSULIN-SECRETION IN THE PERFUSED RAT PANCREAS [J].

KADOWAKI, S ;

NORMAN, AW .

DIABETES, 1985, 34 (04) :315-320

[9] STUDIES ON THE MODE OF ACTION OF VITAMIN-D .52. DIETARY VITAMIN-D IS ESSENTIAL FOR NORMAL INSULIN-SECRETION FROM THE PERFUSED RAT PANCREAS [J].

KADOWAKI, S ;

NORMAN, AW .

JOURNAL OF CLINICAL INVESTIGATION, 1984, 73 (03) :759-766

[10]

KIRK RL, 1982, CLINICOGENETIC GENES, P34

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