Inflammation and cancer: A double-edged sword

被引:120
作者
Hagemann, Thorsten
Balkwill, Frances
Lawrence, Toby
机构
[1] Barts & London Queen Marys Sch Med & Dent, Inst Canc, Ctr Translat Oncol, London EC1M 6BQ, England
[2] Barts & London Queen Marys Sch Med & Dent, CR UK Clin Ctr, London EC1M 6BQ, England
基金
英国医学研究理事会;
关键词
D O I
10.1016/j.ccr.2007.10.005
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Recent literature has highlighted an important role of inflammation in promoting cancer. However, the immune system can also play a central role in protecting the body against cancer as well as infection, although its role in cancer is not well understood. A study published in the September issue of Nature Medicine adds a new twist to the role of inflammation in cancer. Apetoh et al. describe how activation of innate immunity after conventional radiation or chemotherapy can trigger protective antitumor immunity.
引用
收藏
页码:300 / 301
页数:2
相关论文
共 13 条
[1]   Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy [J].
Apetoh, Lionel ;
Ghiringhelli, Francois ;
Tesniere, Antoine ;
Obeid, Michel ;
Ortiz, Carla ;
Criollo, Alfredo ;
Mignot, Gregoire ;
Maiuri, M. Chiara ;
Ullrich, Evelyn ;
Saulnier, Patrick ;
Yang, Huan ;
Amigorena, Sebastian ;
Ryffel, Bernard ;
Barrat, Franck J. ;
Saftig, Paul ;
Levi, Francis ;
Lidereau, Rosette ;
Nogues, Catherine ;
Mira, Jean-Paul ;
Chompret, Agnes ;
Joulin, Virginie ;
Clavel-Chapelon, Francoise ;
Bourhis, Jean ;
Andre, Fabrice ;
Delaloge, Suzette ;
Tursz, Thomas ;
Kroemer, Guido ;
Zitvogel, Laurence .
NATURE MEDICINE, 2007, 13 (09) :1050-1059
[2]  
Ardavin Carlos, 2004, Immunity, V20, P17, DOI 10.1016/S1074-7613(03)00352-2
[3]   Smoldering and polarized inflammation in the initiation and promotion of malignant disease [J].
Balkwill, F ;
Charles, KA ;
Mantovani, A .
CANCER CELL, 2005, 7 (03) :211-217
[4]   BCG (Bacillus of Calmette Guerin) therapy of high-risk superficial bladder cancer [J].
Bassi, PF .
SURGICAL ONCOLOGY-OXFORD, 2002, 11 (1-2) :77-83
[5]  
Coley W. B., 1894, T AM SURG ASS, V12, P183
[6]   IKKβ links inflammation and tumorigenesis in a mouse model of colitis-associated cancer [J].
Greten, FR ;
Eckmann, L ;
Greten, TF ;
Park, JM ;
Li, ZW ;
Egan, LJ ;
Kagnoff, MF ;
Karin, M .
CELL, 2004, 118 (03) :285-296
[7]   Sex, cytokines, and cancer [J].
Lawrence, Toby ;
Hagemann, Thorsten ;
Balkwill, Frances .
SCIENCE, 2007, 317 (5834) :51-52
[8]   High-mobility group box 1 protein (HMGB): Nuclear weapon in the immune arsenal [J].
Lotze, MT ;
Tracey, KJ .
NATURE REVIEWS IMMUNOLOGY, 2005, 5 (04) :331-342
[9]   IKKβ is required for prevention of apoptosis mediated by cell-bound but not by circulating TNFα [J].
Maeda, S ;
Chang, LF ;
Li, ZW ;
Luo, JL ;
Leffert, H ;
Karin, M .
IMMUNITY, 2003, 19 (05) :725-737
[10]   Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes [J].
Mantovani, A ;
Sozzani, S ;
Locati, M ;
Allavena, P ;
Sica, A .
TRENDS IN IMMUNOLOGY, 2002, 23 (11) :549-555