Cell Reprogramming: A New Chemical Approach to Stem Cell Biology and Tissue Regeneration

被引：7

作者：

Anastasia, L. ^{[1
,2
]}

Piccoli, M. ^{[1
,2
]}

Garatti, A. ^{[2
]}

Conforti, E. ^{[2
]}

Scaringi, R. ^{[1
,2
]}

Bergante, S. ^{[1
,2
]}

Castelvecchio, S. ^{[2
]}

Venerando, B. ^{[1
,2
]}

Menicanti, L. ^{[2
]}

Tettamanti, G. ^{[2
]}

机构：

[1] Univ Milan, Dept Med Chem Biochem & Biotechnol, Milan, Italy

[2] IRCCS Policlin San Donato, Lab Stem Cell Tissue Engn, San Donato Milanese, Italy

来源：

CURRENT PHARMACEUTICAL BIOTECHNOLOGY | 2011年 / 12卷 / 02期

关键词：

Stem cell; chemical molecules reprogramming stem cell; tissue regeneration; LINEAGE-COMMITTED CELLS; REVERSINE INCREASES; MURINE FIBROBLASTS; NUCLEAR TRANSFER; GROWTH ARREST; SOMATIC-CELLS; IN-VITRO; INDUCTION; GENERATION; MOLECULE;

D O I：

10.2174/138920111794295828

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Generation of pluripotent stem cells (iPSCs) from adult fibroblasts starts a "new era" in stem cell biology, as it overcomes several key issues associated with previous approaches, including the ethical concerns associated with human embryonic stem cells. However, as the genetic approach for cell reprogramming has already shown potential safety issues, a chemical approach may be a safer and easier alternative. Moreover, a chemical approach could be advantageous not only for the de-differentiation phase, but also for inducing reprogrammed cells into the desired cell type with higher efficiency than current methodologies. Finally, a chemical approach may be envisioned to activate resident adult stem cells to proliferate and regenerate damaged tissues in situ, without the need for exogenous cell injections.

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页码：146 / 150

页数：5

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