Modulation of developmental signals by endocytosis: different means and many ends

被引：47

作者：

Piddini, E ^{[1
]}

Vincent, JP ^{[1
]}

机构：

[1] Natl Inst Med Res, London NW7 1AA, England

来源：

CURRENT OPINION IN CELL BIOLOGY | 2003年 / 15卷 / 04期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0955-0674(03)00072-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent advances have highlighted the importance of endocytic processes in regulating the activity and distribution of developmental signals. Classically, signalling is downregulated by endocytosis and subsequent trafficking to lysosomes (e.g. Notch, Hedgehog, Roundabout). However, endocytosis can also have a positive role in signalling. For example, endocytosis of Delta, the ligand of Notch, is needed for activation of the signal. In the case of signalling by Hedgehog, endocytic trafficking segregates an inhibitory receptor (Patched) from the positive effector (Smoothened). Endosomes could also be the site where signalling is activated (e.g. transforming growth factor beta). Finally, endocytosis could power the transport of morphogens along epithelia.

引用

页码：474 / 481

页数：8

共 46 条

[1] Posttranscriptional regulation of smoothened is part of a self-correcting mechanism in the hedgehog signaling system [J].