Randomised controlled trial of intensive cognitive behaviour therapy for patients with chronic schizophrenia

被引:281
作者
Tarrier, N [1 ]
Yusupoff, L
Kinney, C
McCarthy, E
Gledhill, A
Haddock, G
Morris, J
机构
[1] Univ Manchester, Withington Hosp, Sch Psychiat & Behav Sci, Dept Clin Psychol, Manchester M20 8LR, Lancs, England
[2] Univ Manchester, Dept Med Stat, Manchester M20 8LR, Lancs, England
基金
英国惠康基金;
关键词
D O I
10.1136/bmj.317.7154.303
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives: To investigate whether intensive cognitive behaviour therapy results in significant improvement in positive psychotic symptoms in patients with chronic schizophrenia. Design: Patients with chronic schizophrenia were randomly allocated, stratified according to severity of symptoms and sex, to intensive cognitive behaviour therapy and routine care, supportive counselling and routine care, and routine care alone. Setting: Adjunct treatments were carried out in outpatient clinics or in the patient's home. Subjects: 87 patients with persistent positive symptoms who complied with medication; 72 completed treatment. Outcome measures: Assessments of positive psychotic symptoms before treatment and 3 months after treatment. Number of patients who showed a 50% or more improvement in symptoms. Exacerbation of symptoms and rates of readmission to hospital. Results: Significant improvements were found in the severity (F = 5.42, df = 2,86; P = 0.006) and number (F = 4.99, df = 2,86; P = 0.009) of positive symptoms in those treated with cognitive behaviour therapy. The supportive counselling group showed a non-significant improvement Significantly more patients treated with cognitive behaviour therapy showed an improvement of 50% or more in their symptoms (chi(2) = 5.18, df = 1; P = 0.02). Logistic regression indicated that receipt of cognitive behaviour therapy results in almost eight times greater odds (odds ratio 7.88) of showing this improvement The group receiving routine care alone also experienced more exacerbations and days spent in hospital. Conclusions: Cognitive behaviour therapy is a potentially useful adjunct treatment in the management of patients with chronic schizophrenia.
引用
收藏
页码:303 / 307
页数:7
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