Conjugates of Tremella polysaccharides with microbeads and their TNF-stimulating activity

被引：13

作者：

Gao, QP

Berntzen, G

Jiang, RZ

Killie, MK

Seljelid, R ^{[1
]}

机构：

[1] Univ Tromso, IMB, Dept Expt Pathol, N-9037 Tromso, Norway

[2] Acad Chinese Tradit Med & Mat Med Jilin Prov, Changchun, Peoples R China

来源：

PLANTA MEDICA | 1998年 / 64卷 / 06期

关键词：

Tremella fuciformis; Tremellaceae; mannan heteroglycan; microbeads conjugate; cytokine-stimulating activity;

D O I：

10.1055/s-2006-957512

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A mannan (A) and a heteroglycan (D) were prepared by partial acidic hydrolysis of T3, a major polysaccharide fraction of the fungus Tremella fuciformis Berk. Methylation analysis of A and D showed that they contained a 1 --> linked mannosyl main chain, to which were linked different side chains at positions 2, 4, or 6 of the mannosyl residues. A and D were conjugated to albumin microbeads (AM) by reductive amination, The conjugates showed significant cytokine-stimulating activity in vitro whereas unconjugated AM had no activity. Not conjugated A and D showed cytokine-stimulating activity only in about 100 times higher concentrations.

引用

页码：551 / 554

页数：4

共 20 条

[1] NEW METHOD FOR QUANTITATIVE-DETERMINATION OF URONIC ACIDS [J].