Synthesis of biotinylated glycosulfopeptides by chemoselective ligation

被引：13

作者：

Durieux, P ^{[1
]}

Fernandez-Carneado, J ^{[1
]}

Tuchscherer, G ^{[1
]}

机构：

[1] Univ Lausanne, Inst Organ Chem, CH-1015 Lausanne, Switzerland

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 12期

关键词：

peptide conjugates; biotinylated glycosulfopeptides; chemoselective ligation; PSGL-1; mimetics;

D O I：

10.1016/S0040-4039(01)00167-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Tyrosine sulfation and O-glycosylation are two post-translational modifications playing an essential rule in modulation of biological activity, protein folding and cellular communication. Here, a novel chemical approach for the synthesis of biotinylated glycosulfopeptides is described based on a combination of acid labile protecting groups, highly acid sensitive resins and two orthogonal chemoselective ligation reactions. (C) 2001 Published by Elsevier Science Ltd.

引用

页码：2297 / 2299

页数：3

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