A new approach to decoding life: Systems biology

被引：1072

作者：

Ideker, T ^{[1
]}

Galitski, T

Hood, L

机构：

[1] Inst Syst Biol, Seattle, WA 98105 USA

[2] Univ Washington, Dept Mol Biotechnol, Seattle, WA 98195 USA

[3] Univ Washington, Dept Immunol, Seattle, WA 98195 USA

[4] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA

[5] Univ Washington, Dept Comp Sci & Engn, Seattle, WA 98195 USA

来源：

ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS | 2001年 / 2卷

关键词：

biological information; discovery sciences; genome; proteome;

D O I：

10.1146/annurev.genom.2.1.343

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Systems biology studies biological systems by systematically perturbing them (biologically, genetically, or chemically); monitoring the gene, protein, and informational pathway responses; integrating these data; and ultimately, formulating mathematical models that describe the structure of the system and its response to individual perturbations. The emergence of systems biology is described, as are several examples of specific systems approaches.

引用

页码：343 / 372

页数：34

共 144 条

[1] Systematic management and analysis of yeast gene expression data [J].

Aach, J ;

Rindone, W ;

Church, GM .

GENOME RESEARCH, 2000, 10 (04) :431-445

[2] The genome sequence of Drosophila melanogaster [J].

Adams, MD ;

Celniker, SE ;

Holt, RA ;

Evans, CA ;

Gocayne, JD ;

Amanatides, PG ;

Scherer, SE ;

Li, PW ;

Hoskins, RA ;

Galle, RF ;

George, RA ;

Lewis, SE ;

Richards, S ;

Ashburner, M ;

Henderson, SN ;

Sutton, GG ;

Wortman, JR ;

Yandell, MD ;

Zhang, Q ;

Chen, LX ;

Brandon, RC ;

Rogers, YHC ;

Blazej, RG ;

Champe, M ;

Pfeiffer, BD ;

Wan, KH ;

Doyle, C ;

Baxter, EG ;

Helt, G ;

Nelson, CR ;

Miklos, GLG ;

Abril, JF ;

Agbayani, A ;

An, HJ ;

Andrews-Pfannkoch, C ;

Baldwin, D ;

Ballew, RM ;

Basu, A ;

Baxendale, J ;

Bayraktaroglu, L ;

Beasley, EM ;

Beeson, KY ;

Benos, PV ;

Berman, BP ;

Bhandari, D ;

Bolshakov, S ;

Borkova, D ;

Botchan, MR ;

Bouck, J ;

Brokstein, P .

SCIENCE, 2000, 287 (5461) :2185-2195

[3]

Akutsu T, 1998, P ACM SIAM S DISCR A

[4] Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays [J].

Alon, U ;

Barkai, N ;

Notterman, DA ;

Gish, K ;

Ybarra, S ;

Mack, D ;

Levine, AJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (12) :6745-6750

[5] Robustness in bacterial chemotaxis [J].

Alon, U ;

Surette, MG ;

Barkai, N ;

Leibler, S .

NATURE, 1999, 397 (6715) :168-171

[6] Automatic extraction of keywords from scientific text: application to the knowledge domain of protein families [J].

Andrade, MA ;

Valencia, A .

BIOINFORMATICS, 1998, 14 (07) :600-607

[7]

[Anonymous], ELECT CIRCUIT SYSTEM

[8]

Arkin A, 1998, GENETICS, V149, P1633

[9] STATISTICAL CONSTRUCTION OF CHEMICAL-REACTION MECHANISMS FROM MEASURED TIME-SERIES [J].

ARKIN, A ;

ROSS, J .

JOURNAL OF PHYSICAL CHEMISTRY, 1995, 99 (03) :970-979

[10]

Arnone MI, 1997, DEVELOPMENT, V124, P1851

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