Pathogenesis and treatment of Ph+ leukemia:: recent insights from mouse models

被引：10

作者：

Van Etten, RA

机构：

[1] Ctr Blood Res, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

来源：

CURRENT OPINION IN HEMATOLOGY | 2001年 / 8卷 / 04期

关键词：

D O I：

10.1097/00062752-200107000-00008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Several methods to model human Ph+ leukemia in laboratory mice are available, including propagation of BCR/ABL-expressing cells in mice, xenotransplantation of primary Ph+ leukemia cells into immunodeficient mice, BCR/ABL transgenic mice, and BCR/ABL retroviral bone marrow transduction and transplantation. Recent studies in these different model systems have yielded important advances in our knowledge of the pathogenesis and therapy of human chronic myeloid leukemia and Ph+ B-lymphoblastic leukemia, and are the subject of this review. (C) 2001 Lippincott Williams & Wilkins, Inc.

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页码：224 / 230

页数：7

相关论文

共 56 条

[1] BCR-ABL-MEDIATED INHIBITION OF APOPTOSIS WITH DELAY OF G2/M TRANSITION AFTER DNA-DAMAGE - A MECHANISM OF RESISTANCE TO MULTIPLE ANTICANCER AGENTS [J].

BEDI, A ;

BARBER, JP ;

BEDI, GC ;

ELDEIRY, WS ;

SIDRANSKY, D ;

VALA, MS ;

AKHTAR, AJ ;

HILTON, J ;

JONES, RJ .

BLOOD, 1995, 86 (03) :1148-1158

[2] Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell [J].

Bonnet, D ;

Dick, JE .

NATURE MEDICINE, 1997, 3 (07) :730-737

[3] Mutator phenotype of BCR-ABL transfected Ba/F3 cell lines and its association with enhanced expression of DNA polymerase β [J].

Canitrot, Y ;

Lautier, D ;

Laurent, G ;

Fréchet, M ;

Ahmed, A ;

Turhan, AG ;

Salles, B ;

Cazaux, C ;

Hoffmann, JS .

ONCOGENE, 1999, 18 (17) :2676-2680

[4]

CESANO A, 1992, ONCOGENE, V7, P827

[5] A primitive hematopoietic cell is the target for the leukemic transformation in human Philadelphia-positive acute lymphoblastic leukemia [J].

Cobaleda, C ;

Gutiérrez-Cianca, N ;

Pérez-Losada, J ;

Flores, T ;

García-Sanz, R ;

González, M ;

Sánchez-García, I .

BLOOD, 2000, 95 (03) :1007-1013

[6] INDUCTION OF CHRONIC MYELOGENOUS LEUKEMIA IN MICE BY THE P210BCR/ABL GENE OF THE PHILADELPHIA-CHROMOSOME [J].

DALEY, GQ ;

VANETTEN, RA ;

BALTIMORE, D .

SCIENCE, 1990, 247 (4944) :824-830

[7] The kinetics and extent of engraftment of chronic myelogenous leukemia cells in non-obese diabetic/severe combined immunodeficiency mice reflect the phase of the donor's disease: An in vivo model of chronic myelogenous leukemia biology [J].

Dazzi, F ;

Capelli, D ;

Hasserjian, R ;

Cotter, F ;

Corbo, M ;

Poletti, A ;

Chinswangwatanakul, W ;

Goldman, JM ;

Gordon, MY .

BLOOD, 1998, 92 (04) :1390-1396

[8]

DRUKER BJ, 2001, NEW ENGL J MED, V344, P1084

[9] Regulated expression of P210 Bcr-Abl during embryonic stem cell differentiation stimulates multipotential progenitor expansion and myeloid cell fate [J].

Era, T ;

Witte, ON .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (04) :1737-1742

[10] Role of α1 acid glycoprotein in the in vivo resistance of human BCR-ABL+ leukemic cells to the Abl inhibitor STI571 [J].

Gambacorti-Passerini, C ;

Barni, R ;

le Coutre, P ;

Zucchetti, M ;

Cabrita, G ;

Cleris, L ;

Rossi, F ;

Gianazza, E ;

Brueggen, J ;

Cozens, R ;

Pioltelli, P ;

Pogliani, E ;

Corneo, G ;

Formelli, F ;

D'Incalci, M .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2000, 92 (20) :1641-1650

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