Significantly Improved Analytical Sensitivity of Lateral Flow Immunoassays by Using Thermal Contrast

被引：168

作者：

Qin, Zhenpeng ^{[1
]}

Chan, Warren C. W. ^{[5
,6
]}

Boulware, David R. ^{[4
]}

Akkin, Taner ^{[2
]}

Butler, Elissa K. ^{[4
]}

Bischof, John C. ^{[1
,2
,3
]}

机构：

[1] Univ Minnesota, Dept Mech Engn, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Dept Biomed Engn, Minneapolis, MN 55455 USA

[3] Univ Minnesota, Dept Urol, Minneapolis, MN 55455 USA

[4] Univ Minnesota, Dept Med, Ctr Infect Dis & Microbiol Translat Res, Minneapolis, MN 55455 USA

[5] Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON, Canada

[6] Univ Toronto, Terrence Donnelly Ctr Cellular & Biomol Res, Toronto, ON, Canada

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 18期

基金：

美国国家科学基金会;

关键词：

biosensors; diagnostics; immunoassays; nanoparticles; thermal contrast; RECONSTITUTION INFLAMMATORY SYNDROME; CRYPTOCOCCAL MENINGITIS; METAL NANOPARTICLES; GOLD NANOPARTICLES; OPTICAL-PROPERTIES; HIV; THERAPY; SERUM; MICROFLUIDICS; BIOMEDICINE;

D O I：

10.1002/anie.201200997

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Heat beyond visual: The thermal contrast from the heating of gold nanoparticles upon laser stimulation can improve the analytical sensitivity of lateral flow assays (LFAs; see picture). A 32-fold improvement in sensitivity of an approved LFA for cryptococcal antigen (purple diamond) was shown, with the potential for further improvement by optimizing the backing material and the properties of the antibody-coated nanoparticles (red circle with blue Y). Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：4358 / 4361

页数：4

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