Conversion of 1,3-disubstituted arenes to chiral α,α-diaryl methylammonium chlorides using arene borylation

被引：23

作者：

Boebel, Timothy A. ^{[1
]}

Hartwig, John F. ^{[1
]}

机构：

[1] Univ Illinois, Dept Chem, Urbana, IL 61801 USA

来源：

TETRAHEDRON | 2008年 / 64卷 / 29期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/j.tet.2008.04.060

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A two-step conversion of 1,3-disubstituted arenes to chiral alpha,alpha-diaryl methylammonium chlorides is described. In this procedure, arenes are converted to aryl boronic esters by iridium-catalyzed borylation, and the aryl boronic esters are converted to enantioenriched amines by subsequent rhodium-catalyzed addition to chiral tert-butanesulfinimes. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：6824 / 6830

页数：7

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