Association of fetal inflammation and coagulation pathway gene polymorphisms with neurodevelopmental delay at age 2 years

被引：19

作者：

Clark, Erin A. S. ^{[1
]}

Mele, Lisa ^{[15
]}

Wapner, Ronald J. ^{[2
]}

Spong, Catherine Y. ^{[16
]}

Sorokin, Yoram ^{[3
]}

Peaceman, Alan ^{[4
]}

Iams, Jay D. ^{[5
]}

Leveno, Kenneth J. ^{[6
]}

Harper, Margaret ^{[7
]}

Caritis, Steve N. ^{[8
]}

Miodovnik, Menachem ^{[9
]}

Mercer, Brian M. ^{[10
]}

Thorp, John M. ^{[11
]}

Ramin, Susan M. ^{[12
]}

Carpenter, Marshall ^{[13
]}

Rouse, Dwight J. ^{[14
]}

机构：

[1] Univ Utah, Sch Med, Dept Obstet & Gynecol, Salt Lake City, UT 84132 USA

[2] Drexel Univ, Philadelphia, PA 19104 USA

[3] Wayne State Univ, Detroit, MI USA

[4] Northwestern Univ, Chicago, IL 60611 USA

[5] Ohio State Univ, Columbus, OH 43210 USA

[6] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA

[7] Wake Forest Univ, Winston Salem, NC 27109 USA

[8] Univ Pittsburgh, Pittsburgh, PA USA

[9] Columbia Univ, New York, NY USA

[10] Case Western Reserve Univ, Cleveland, OH 44106 USA

[11] Univ N Carolina, Chapel Hill, NC USA

[12] Univ Texas Houston, Hlth Sci Ctr, Houston, TX USA

[13] Brown Univ, Providence, RI 02912 USA

[14] Univ Alabama Birmingham, Birmingham, AL USA

[15] George Washington Univ, Ctr Biostat, Washington, DC USA

[16] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Bethesda, MD USA

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 2010年 / 203卷 / 01期

关键词：

gene polymorphism; neurodevelopmental delay; single-nucleotide polymorphism; ALPHA-GENE; INTERLEUKIN-6; ATOPY; SINGLE;

D O I：

10.1016/j.ajog.2010.01.047

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

OBJECTIVE: The purpose of this study was to evaluate the association between fetal inflammation and coagulation gene single-nucleotide polymorphisms (SNPs) and neurodevelopmental delay at age 2 years. STUDY DESIGN: We conducted a case-controlled secondary analysis of a randomized trial of single-vs multiple-course corticosteroids. Multiplex assay assessed 46 SNPs. Cases had mental developmental and/or psychomotor delay at age 2 years. Control subjects had normal neurodevelopment. RESULTS: One hundred twenty-five cases and 147 control subjects were analyzed. Allele frequencies were different between cases and control subjects for interleukin (IL) 1 beta-511 (P = .009), IL4R-148 (P = .03), IL6-174 (P = .02), and IL6-176 (P = .007). Genotype frequencies were different for IL1 beta-511 (P = .03) and IL6-174 (P = .04). Results for IL1 beta-511, IL4R-148, and IL6-176 remained significant after logistic regression analysis. IL1 beta-511 and IL6-176 minor alleles were associated with increased risk of neurodevelopmental delay (odds ratio, 3.1; 95% confidence interval [CI], 1.2-8.2 and 2.2; 95% CI, 1.2-3.9, respectively). IL4R-148 minor allele was protective (odds ratio, 0.6; 95% CI, 0.4-0.9). CONCLUSION: Fetal SNPs in IL1 beta, IL-4R, and IL-6 may be associated with neurodevelopmental delay at age 2 years.

引用

页码：83.e1 / 83.e10

页数：10

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