Design, synthesis and X-ray crystallographic studies of [7.3.1] and [8.3.1] macrocyclic FKBP-12 ligands

被引：10

作者：

Babine, RE

Bleckman, TM

Littlefield, ES

Parge, HE

Pelletier, LAK

Lewis, CT

French, JV

Imbacuan, M

Katoh, S

Tatlock, JH

Showalter, RE

Ernest, J

机构：

[1] Agouron Pharmaceuticals, Inc., San Diego, CA 92121-1121

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 04期

关键词：

D O I：

10.1016/0960-894X(96)00032-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The design, synthesis, and structure activity relationships of a series of novel macrocyclic FKBP-12 ligands 1 are reported. The crystal structure of the complex between 7 and human FKBP-12 is reported and some SAR results are discussed based on this complex.

引用

页码：385 / 390

页数：6

共 18 条

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