Effect of both elevated troponin-I and peripheral white blood cell count on prognosis in patients with suspected myocardial injury

被引：6

作者：

Zahid, M

Sonel, AF

Kelley, ME

Wall, L

Whittle, J

Fine, MJ

Good, CB

机构：

[1] VA Pittsburgh Healthcare Syst, Ctr Hlth Equ Res & Promot, Pittsburgh, PA USA

[2] Univ Pittsburgh, Cardiovasc Inst, Pittsburgh, PA 15260 USA

[3] Univ Kansas, Kansas City, MO USA

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2005年 / 95卷 / 08期

关键词：

D O I：

10.1016/j.amjcard.2004.12.037

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We found a high white blood cell count (> 11,000/mu l) to be of additive prognostic value to high troponin-l levels in predicting risk of recurrent nonfatal myocardial infarctions and all-cause mortality in patients who present with acute coronary syndromes and non-ST-elevation myocardial infarctions. A high troponin-I level or white blood cell count increased the odds ratio of an event to 2.2 (95% confidence interval 1.0 to 4.73, p = 0.05), but high values for the 2 markers increased the odds ratio to 4.5 (95% confidence interval 1.42 to 14.21, p = 0.01). (c) 2005 by Excerpta Medica Inc.

引用

页码：970 / 972

页数：3

共 14 条

[1] Association between white blood cell count, epicardial blood flow, myocardial perfusion, and clinical outcomes in the setting of acute myocardial infarction - A Thrombolysis in Myocardial Infarction 10 substudy [J].

Barron, HV ;

Cannon, CP ;

Murphy, SA ;

Braunwald, E ;

Gibson, CM .

CIRCULATION, 2000, 102 (19) :2329-2334

[2] Effect of revascularization on mortality associated with an elevated white blood cell count in acute coronary syndromes [J].

Bhatt, DL ;

Chew, DP ;

Lincoff, AM ;

Simoons, ML ;

Harrington, RA ;

Ommen, SR ;

Jia, G ;

Topol, EJ .

AMERICAN JOURNAL OF CARDIOLOGY, 2003, 92 (02) :136-140

[3] Widespread coronary inflammation in unstable angina [J].

Buffon, A ;

Biasucci, LM ;

Liuzzo, G ;

D'Onofrio, G ;

Crea, F ;

Maseri, A .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (01) :5-12

[4] Association of white blood cell count with increased mortality in acute myocardial infarction and unstable angina pectoris [J].

Cannon, CP ;

McCabe, CH ;

Wilcox, RG ;

Bentley, JH ;

Braunwald, E .

AMERICAN JOURNAL OF CARDIOLOGY, 2001, 87 (05) :636-639

[5] American College of Cardiology key data elements and definitions for measuring the clinical management and outcomes of patients with acute coronary syndromes - A report of the American College of Cardiology Task Force on Clinical Data Standards (Acute Coronary Syndromes Writing Committee) [J].

Cannon, CP ;

Battler, A ;

Brindis, RG ;

Cox, JL ;

Ellis, SG ;

Every, NR ;

Flaherty, JT ;

Harrington, RA ;

Krumholz, HM ;

Simoons, ML ;

Van de Werf, FJJ ;

Weintraub, WS ;

Mitchell, KR ;

Morrisson, SL ;

Brandis, RG ;

Anderson, HV ;

Cannom, DS ;

Chitwood, WR ;

Cigarroa, JE ;

Collins-Nakai, RL ;

Ellis, SG ;

Gibbons, RJ ;

Grover, FL ;

Heidenreich, PA ;

Khandheria, BK ;

Knoebel, SB ;

Krumholz, HL ;

Malenka, DJ ;

Mark, DB ;

McKay, CR ;

Passamani, ER ;

Radford, MJ ;

Riner, RN ;

Schwartz, JB ;

Shaw, RE ;

Shemin, RJ ;

Van Fossen, DB ;

Verrier, ED ;

Watkins, MW ;

Phoubandith, DR ;

Furnelli, T .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2001, 38 (07) :2114-2130

[6] P-SELECTIN INDUCES THE EXPRESSION OF TISSUE FACTOR ON MONOCYTES [J].

CELI, A ;

PELLEGRINI, G ;

LORENZET, R ;

DEBLASI, A ;

READY, N ;

FURIE, BC ;

FURIE, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (19) :8767-8771

[7] C-REACTIVE PROTEIN INDUCES HUMAN PERIPHERAL-BLOOD MONOCYTES TO SYNTHESIZE TISSUE FACTOR [J].

CERMAK, J ;

KEY, NS ;

BACH, RR ;

BALLA, J ;

JACOB, HS ;

VERCELLOTTI, GM .

BLOOD, 1993, 82 (02) :513-520

[8] Assessment of vital status in Department of Veterans Affairs national databases: Comparison with state death certificates [J].

Dominitz, JA ;

Maynard, C ;

Boyko, EJ .

ANNALS OF EPIDEMIOLOGY, 2001, 11 (05) :286-291

[9]

ENGLER RL, 1983, AM J PATHOL, V111, P98

[10] Circulating monocyte-platelet aggregates are an early marker of acute myocardial infarction [J].

Furman, MI ;

Barnard, MR ;

Krueger, LA ;

Fox, ML ;

Shilale, EA ;

Lessard, DM ;

Marchese, P ;

Frelinger, AL ;

Goldberg, RJ ;

Michelson, AD .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2001, 38 (04) :1002-1006

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