Prevention of chemically induced diabetes mellitus in experimental animals by polyunsaturated fatty acids

被引:126
作者
Mohan, IK [1 ]
Das, UN [1 ]
机构
[1] EFA Sci LLC, Norwood, MA 02062 USA
关键词
essential fatty-acid deficiency; conjugated linoleic acid; peroxisome proliferator-activated receptor-gamma; troglitazone; diabetes mellitus;
D O I
10.1016/S0899-9007(00)00468-8
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Previous studies showed that essential fatty-acid deficiency, conjugated linoleic acid, and a peroxisome proliferator-activated receptor-gamma binding agent such as troglitazone can prevent the development of diabetes mellitus in experimental animals. In the present study, we observed that oral supplementation with oils rich in omega -3 eicosspentaenoic acid and docosahexaenoic acid and omega -6 gamma -linolenic acid and arachidonic acid could protect the animals against alloxan-induced diabetes mellitus. These oils rich in omega -3 and omega -6 fatty acids not only significantly attenuated chemical-induced diabetes mellitus but also restored the antioxidant status to normal range. Changes in the concentrations of different fatty acids shown by the phospholipid fractions of plasma, liver, and muscle tissues that occurred as a result of alloxan-induced diabetes mellitus also reverted to normal in these animals. Based on these results and the known mechanisms of alloxan, we suggest that omega -3 and omega -6 long-chain fatty acids can prevent chemically induced diabetes mellitus by enhancing the antioxidant status and suppressing production of cytokines. (C) Elsevier Science Inc. 2001.
引用
收藏
页码:126 / 151
页数:26
相关论文
共 69 条
[1]   ESSENTIAL FATTY-ACID DEFICIENCY PREVENTS AUTOIMMUNE DIABETES IN NONOBESE DIABETIC MICE THROUGH A POSITIVE IMPACT ON ANTIGEN-PRESENTING CELLS AND TH2 LYMPHOCYTES [J].
BENHAMOU, PY ;
MULLEN, Y ;
CLARESALZLER, M ;
SANGKHARAT, A ;
BENHAMOU, C ;
SHEVLIN, L ;
GO, VLW .
PANCREAS, 1995, 11 (01) :26-37
[2]  
BERNHEIM F, 1948, J BIOL CHEM, V174, P257
[3]   FACTORS AFFECTING BETA-CELL SENSITIVITY TO ALLOXAN INVIVO - INFLUENCE OF PRETREATMENT AND POST-TREATMENT WITH PROTECTIVE SUBSTANCES [J].
BOQUIST, L .
ACTA ENDOCRINOLOGICA, 1978, 88 (03) :556-561
[4]   EFFECTS INVITRO OF ALLOXAN ON THE GLUCOSE-METABOLISM OF MOUSE PANCREATIC B-CELLS [J].
BORG, LAH ;
EIDE, SJ ;
ANDERSSON, A ;
HELLERSTROM, C .
BIOCHEMICAL JOURNAL, 1979, 182 (03) :797-802
[5]  
CAMPBELL IL, 1988, J IMMUNOL, V141, P2325
[6]  
CATALASE AH, 1984, OXYGEN RADICALS BIOL, P121
[7]  
Chew BP, 1997, ANTICANCER RES, V17, P1099
[8]   EFFECTS OF DIETARY FATS ON FATTY-ACID COMPOSITION AND DELTA-5 DESATURASE IN NORMAL AND DIABETIC RATS [J].
DANG, AQ ;
KEMP, K ;
FAAS, FH ;
CARTER, WJ .
LIPIDS, 1989, 24 (10) :882-889
[9]  
Das U. N., 1994, Journal of Nutritional Medicine, V4, P149, DOI 10.3109/13590849409034550
[10]  
Das U N, 1999, J Assoc Physicians India, V47, P906