The ribosome at atomic resolution

被引：23

作者：

Moore, PB ^{[1
]}

机构：

[1] Yale Univ, Dept Chem, New Haven, CT 06520 USA

[2] Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT 06520 USA

来源：

BIOCHEMISTRY | 2001年 / 40卷 / 11期

关键词：

D O I：

10.1021/bi0029402

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The publication of atomic resolution crystal structures for the large ribosomal subunit from Haloarcula marismortui and the small ribosomal subunit from Thermus thermophilus has permanently altered the way protein synthesis is conceptualized and experiments designed to address its unresolved issues. The impact of these structures on RNA biochemistry is certain to be no less profound. The background and substance of these developments are reviewed here.

引用

收藏

页码：3243 / 3250

页数：8

相关论文

共 54 条

[1] Visualization of tRNA movements on the Escherichia coli 70S ribosome during the elongation cycle [J].

Agrawal, RK ;

Spahn, CMT ;

Penczek, P ;

Grassucci, RA ;

Nierhaus, KH ;

Frank, J .

JOURNAL OF CELL BIOLOGY, 2000, 150 (03) :447-459

[2] EF-G-dependent GTP hydrolysis induces translocation accompanied by large conformational changes in the 70S ribosome [J].

Agrawal, RK ;

Heagle, AB ;

Penczek, P ;

Grassucci, RA ;

Frank, J .

NATURE STRUCTURAL BIOLOGY, 1999, 6 (07) :643-647

[3] CRYSTAL-STRUCTURE OF THE ACTIVE-SITE OF RIBULOSE-BISPHOSPHATE CARBOXYLASE [J].

ANDERSSON, I ;

KNIGHT, S ;

SCHNEIDER, G ;

LINDQVIST, Y ;

LUNDQVIST, T ;

BRANDEN, CI ;

LORIMER, GH .

NATURE, 1989, 337 (6204) :229-234

[4] The complete atomic structure of the large ribosomal subunit at 2.4 Å resolution [J].

Ban, N ;

Nissen, P ;

Hansen, J ;

Moore, PB ;

Steitz, TA .

SCIENCE, 2000, 289 (5481) :905-920

[5] A 9Å resolution x-ray crystallographic map of the large ribosomal subunit [J].

Ban, N ;

Freeborn, B ;

Nissen, P ;

Penczek, P ;

Grassucci, RA ;

Sweet, R ;

Frank, J ;

Moore, PB ;

Steitz, TA .

CELL, 1998, 93 (07) :1105-1115

[6] Placement of protein and RNA structures into a 5 Å-resolution map of the 50S ribosomal subunit [J].

Ban, N ;

Nissen, P ;

Hansen, J ;

Capel, M ;

Moore, PB ;

Steitz, TA .

NATURE, 1999, 400 (6747) :841-847

[7] NASCENT POLYPEPTIDE-CHAINS EMERGE FROM THE EXIT DOMAIN OF THE LARGE RIBOSOMAL-SUBUNIT - IMMUNE MAPPING OF THE NASCENT CHAIN [J].

BERNABEU, C ;

LAKE, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (10) :3111-3115

[8] KINETIC-PROPERTIES OF ESCHERICHIA-COLI RIBOSOMES WITH ALTERED FORMS OF S12 [J].

BILGIN, N ;

CLAESENS, F ;

PAHVERK, H ;

EHRENBERG, M .

JOURNAL OF MOLECULAR BIOLOGY, 1992, 224 (04) :1011-1027

[9]

Blundell T. L., 1976, Protein crystallography

[10] The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit [J].

Brodersen, DE ;

Clemons, WM ;

Carter, AP ;

Morgan-Warren, RJ ;

Wimberly, BT ;

Ramakrishnan, V .

CELL, 2000, 103 (07) :1143-1154

← 1 2 3 4 5 6 →