Manassantin A and B From Saururus chinensis Inhibit Interleukin-6-Induced Signal Transducer and Activator of Transcription 3 Activation in Hep3B Cells

被引：26

作者：

Chang, Jong Sun ^{[1
]}

Lee, Seung Woong ^{[1
]}

Kim, Myo Sun ^{[1
]}

Yun, Bo Ra ^{[1
]}

Park, Mi Hye ^{[1
]}

Lee, Seok-Geun ^{[2
]}

Park, Su-Jin ^{[1
]}

Lee, Woo Song ^{[1
]}

Rho, Mun-Chual ^{[1
]}

机构：

[1] Korea Res Inst Biosci & Biotechnol, Ecofriendly Biomat Res Ctr, Jeongeup Si 580185, Jeonbuk, South Korea

[2] Kyung Hee Univ, Coll Oriental Med, Canc Prevent Mat Dev Res Ctr, Seoul 130701, South Korea

来源：

JOURNAL OF PHARMACOLOGICAL SCIENCES | 2011年 / 115卷 / 01期

关键词：

manassantin A and B; interleukin-6; signal transducer and activator of transcription 3 (Stat3); NF-KAPPA-B; ENDOTHELIAL-CELLS; GENE-EXPRESSION; CANCER-CELLS; PATHWAY;

D O I：

10.1254/jphs.10239SC

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Inhibition of interleukin-6 (IL-6) has been postulated to be an effective therapy in the pathogenesis of several inflammatory diseases. The current study was performed to examine potential effects of manassantin A and B isolated from Saururus chinensis on the IL-6-induced response to human hepatoma cells. We found that manassantin A and B inhibit signal transducer and activator of transcription 3 (Stat3) activity stimulated by IL-6. We also found that both compounds decreased IL-6-induced Stat3 phosphorylation and nuclear translocation. Both compounds blocked suppressor of cytokine signaling 3 (SOCS-3)-mRNA expression induced by IL-6. In addition, we found that Stat3 inhibitory effects of these compounds could be related to protein tyrosine phosphatase. These findings suggest that manassantin A and B could be useful remedies for treatment of inflammatory diseases by inhibiting IL-6 action.

引用

页码：84 / 88

页数：5

共 15 条

[1]

Blaskovich MA, 2003, CANCER RES, V63, P1270

[2]

Herbal remedy magnolol suppresses IL-6-induced STAT3 activation and gene expression in endothelial cells [J].