Genetic dissection of proteoglycan function in Drosophila and C-elegans

被引：57

作者：

Selleck, SB

机构：

[1] Univ Arizona, Dept Mol & Cellular Biol, Tucson, AZ 85724 USA

[2] Arizona Canc Ctr, Tucson, AZ 85724 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2001年 / 12卷 / 02期

关键词：

glycosaminoglycan; C; elegans; Drosophila; proteoglycan;

D O I：

10.1006/scdb.2000.0242

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Genetic analysis of the signaling pathways that govern patterning during development in the fruitfly Drosophila melanogaster and in the nematode C. elegans have provided insight into the in vivo functions of proteoglycans and their associated glycosaminoglycans. These studies have shown that patterning events dictated by Fibroblast Growth Factor Receptors, Wnt, Transforming Growth Factor-beta (TGF-beta), and Hedgehog families of growth factors are regulated by proteoglycans. Recent biochemical and structural analyses have shown that the molecular machinery of glycosaminoglycan biosynthesis is highly conserved between these invertebrate organisms and mammals. Drosophila and C. elegans therefore provide powerful model systems for exploring the varied functions proteoglycans and their glycosaminoglycan modifications.

引用

页码：127 / 134

页数：8

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