Contribution of hematopoietic stem cells to skeletal muscle

被引：187

作者：

Corbel, SY

Lee, A

Yi, L

Duenas, J

Brazelton, TR

Blau, HM

Rossi, FMV

机构：

[1] Univ British Columbia, Biomed Res Ctr, Vancouver, BC V6T 1Z3, Canada

[2] Stanford Univ, Dept Mol Pharmacol, Sch Med, Baxter Lab Genet Pharmacol, Stanford, CA 94305 USA

[3] Stanford Univ, Dept Microbiol & Immunol, Sch Med, Stanford, CA 94305 USA

来源：

NATURE MEDICINE | 2003年 / 9卷 / 12期

关键词：

D O I：

10.1038/nm959

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cells from adult bone marrow participate in the regeneration of damaged skeletal myofibers. However, the relationship of these cells with the various hematopoietic and nonhematopoietic cell types found in bone marrow is still unclear. Here we show that the progeny of a single cell can both reconstitute the hematopoietic system and contribute to muscle regeneration. Integration of bone marrow cells into myofibers occurs spontaneously at low frequency and increases with muscle damage. Thus, classically defined single hematopoietic stem cells can give rise to both blood and muscle.

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页码：1528 / 1532

页数：5

相关论文

共 25 条

[1] Myogenic specification of side population cells in skeletal muscle [J].

Asakura, A ;

Seale, P ;

Girgis-Gabardo, A ;

Rudnicki, MA .

JOURNAL OF CELL BIOLOGY, 2002, 159 (01) :123-134

[2] The evolving concept of a stem cell: Entity or function? [J].

Blau, HM ;

Brazelton, TR ;

Weimann, JM .

CELL, 2001, 105 (07) :829-841

[3] PLASTICITY OF THE DIFFERENTIATED STATE [J].

BLAU, HM ;

PAVLATH, GK ;

HARDEMAN, EC ;

CHIU, CP ;

SILBERSTEIN, L ;

WEBSTER, SG ;

MILLER, SC ;

WEBSTER, C .

SCIENCE, 1985, 230 (4727) :758-766

[4] Significant differences among skeletal muscles in the incorporation of bone marrow-derived cells [J].

Brazelton, TR ;

Nystrom, M ;

Blau, HM .

DEVELOPMENTAL BIOLOGY, 2003, 262 (01) :64-74

[5] A Subpopulation of murine bone marrow cells fully differentiates along the myogenic pathway and participates in muscle repair in the mdx dystrophic mouse [J].

Corti, S ;

Strazzer, S ;

Del Bo, R ;

Salani, S ;

Bossolasco, P ;

Fortunato, F ;

Locatelli, F ;

Soligo, D ;

Moggio, M ;

Ciscato, P ;

Prelle, A ;

Borsotti, C ;

Bresolin, N ;

Scarlato, G ;

Comi, GP .

EXPERIMENTAL CELL RESEARCH, 2002, 277 (01) :74-85

[6] Myotoxic activity of the toxic phospholipase, notexin, from the venom of the Australian tiger snake [J].

Dixon, RW ;

Harris, JB .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1996, 55 (12) :1230-1237

[7] Muscle regeneration by bone marrow derived myogenic progenitors [J].

Ferrari, G ;

Cusella-De Angelis, G ;

Coletta, M ;

Paolucci, E ;

Stornaiuolo, A ;

Cossu, G ;

Mavilio, F .

SCIENCE, 1998, 279 (5356) :1528-1530

[8] Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species [J].

Goodell, MA ;

Rosenzweig, M ;

Kim, H ;

Marks, DF ;

DeMaria, M ;

Paradis, G ;

Grupp, SA ;

Sieff, CA ;

Mulligan, RC ;

Johnson, RP .

NATURE MEDICINE, 1997, 3 (12) :1337-1345

[9] Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo [J].

Goodell, MA ;

Brose, K ;

Paradis, G ;

Conner, AS ;

Mulligan, RC .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 183 (04) :1797-1806

[10] Long-term persistence of donor nuclei in a Duchenne muscular dystrophy patient receiving bone marrow transplantation [J].

Gussoni, E ;

Bennett, RR ;

Muskiewicz, KR ;

Meyerrose, T ;

Nolta, JA ;

Gilgoff, I ;

Stein, J ;

Chan, YM ;

Lidov, HG ;

Bönnemann, CG ;

von Moers, A ;

Morris, GE ;

den Dunnen, JT ;

Chamberlain, JS ;

Kunkel, LM ;

Weinberg, K .

JOURNAL OF CLINICAL INVESTIGATION, 2002, 110 (06) :807-814