Controlling Abl: auto-inhibition and co-inhibition?

被引：79

作者：

Wang, JYJ ^{[1
]}

机构：

[1] Univ Calif San Diego, Div Biol Sci, Mol Biol Sect, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Ctr Canc, La Jolla, CA 92093 USA

来源：

NATURE CELL BIOLOGY | 2004年 / 6卷 / 01期

关键词：

D O I：

10.1038/ncb0104-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Auto-inhibition describes the capacity of proteins to adopt a self-imposed latent conformation. Recently, a crystal structure of the Abl tyrosine kinase has revealed its ability to auto-inhibit. However, a separate body of work suggests that other cellular proteins also inhibit Abl. To reconcile the crystal structure with Abl inhibitors, I propose that Abl is controlled by cellular 'co-inhibitors' that bind Abl, stabilizing the auto-inhibited conformation. The implication of co-inhibition on Abl function is discussed.

引用

页码：3 / 7

页数：5

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