Glucose-Dependent Insulinotropic Polypeptide May Enhance Fatty Acid Re-esterification in Subcutaneous Abdominal Adipose Tissue in Lean Humans

被引:127
作者
Asmar, Meena [1 ,2 ]
Simonsen, Lene [1 ]
Madsbad, Sten [3 ]
Stallknecht, Bente [2 ]
Holst, Jens Juul [2 ]
Bulow, Jens [1 ]
机构
[1] Bispebjerg Hosp, Dept Clin Physiol Nucl Med, DK-2400 Copenhagen, Denmark
[2] Univ Copenhagen, Dept Biomed Sci, Copenhagen, Denmark
[3] Univ Copenhagen, Hvidovre Hosp, Dept Endocrinol, DK-2650 Hvidovre, Denmark
关键词
GASTRIC-INHIBITORY POLYPEPTIDE; BLOOD-FLOW; METABOLISM; GIP; STIMULATION; ADIPOCYTES; PEPTIDE;
D O I
10.2337/db10-0098
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE-Glucose-dependent insulinotropic polypeptide (GIP) has been implicated in lipid metabolism in animals. In humans, however, there is no clear evidence of GIP effecting lipid metabolism. The present experiments were performed in order to elucidate the effects of GIP on regional adipose tissue metabolism. RESEARCH DESIGN AND METHODS-Eight healthy subjects were studied on four different occasions. Abdominal subcutaneous adipose tissue metabolism was assessed by measuring arterio-venous concentration differences and regional adipose tissue blood flow during GIP (1.5 pmol/kg/min) or saline infused intravenously alone or in combination with a hyperinsulinemic-hyperglycemic (HI-HG) clamp. RESULTS-During GIP and HI-HG clamp, abdominal subcutaneous adipose tissue blood flow, hydrolysis of circulating triacylglycerol (TAG) (P = 0.009), and glucose uptake (P = 0.03) increased significantly while free fatty acid (FFA) output (P = 0.04) and FFA/glycerol release ratio (P = 0.02) decreased compared with saline and HI-HG clamp. CONCLUSIONS-In conclusion, GIP in combination with hyperinsulinemia and slight hyperglycemia increased adipose tissue blood flow, glucose uptake, and FFA re-esterification, thus resulting in increased TAG deposition in abdominal subcutaneous adipose tissue. Diabetes 59:2160-2163, 2010
引用
收藏
页码:2160 / 2163
页数:4
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