NSAIDs, gastrointestinal injury, and cytoprotection

被引:133
作者
Scheiman, JM [1 ]
机构
[1] UNIV MICHIGAN,SCH MED,DEPT INTERNAL MED,DIV GASTROENTEROL,ANN ARBOR,MI
关键词
D O I
10.1016/S0889-8553(05)70247-8
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Gastrointestinal toxicity caused by nonsteroidal anti-inflammatory drugs (NSAIDs) is the most frequent drug side effect in the United States. NSAIDs are implicated in the development of complicated peptic ulcer disease and injury to the small bowel and colon. NSAIDs interfere with prostaglandin-mediated epithelial defense mechanisms and also cause direct epithelial toxicity. Current and future approaches to the prevention and management of NSAID injury are reviewed.
引用
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页码:279 / &
页数:21
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