Hereditary immunologic disorders caused by pyrin and cryopyrin

被引：6

作者：

Hoffman, Hal M. ^{[1
]}

机构：

[1] Univ Calif San Diego, Sch Med, Div Rheumatol Allergy & Immunol, La Jolla, CA 92093 USA

来源：

CURRENT ALLERGY AND ASTHMA REPORTS | 2007年 / 7卷 / 05期

关键词：

D O I：

10.1007/s11882-007-0049-4

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

A new family of hereditary immunologic disorders known as the autoinflammatory diseases involves dysregulation of the innate immune system. Elucidation of the genetic basis of these disorders has resulted in improved understanding of the disease pathophysiology of systemic and tissue inflammation, and has also revealed novel nonpathologic innate immune mechanisms. These advances have also resulted in direct improvement in diagnosis and therapy for autoinflammatory disorders such as the cryopyrinopathies and familial Mediterranean fever and have implications for more common inflammatory diseases.

引用

页码：323 / 330

页数：8

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