Syndecan-4 as a molecule involved in defense mechanisms

被引：18

作者：

Ishiguro, K

Kojima, T

Muramatsu, T

机构：

[1] Nagoya Univ, Sch Med, Dept Biochem, Showa Ku, Nagoya, Aichi 4668550, Japan

[2] Nagoya Univ, Sch Med, Dept Internal Med, Showa Ku, Nagoya, Aichi 4668550, Japan

[3] Nagoya Univ, Sch Hlth Sci, Dept Med Technol, Higashi Ku, Aichi 4618673, Japan

来源：

GLYCOCONJUGATE JOURNAL | 2002年 / 19卷 / 4-5期

关键词：

endotoxin shock; IL-1; beta; syndecan-4; TGF-beta; thrombin;

D O I：

10.1023/A:1025308702966

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Syndecan-4 is a transmembrane heparan sulfate proteoglycan belonging to the syndecan family. Syndecan-4-deficient [(Synd4(-/-)] mice were produced to clarify the in vivo role of syndecan-4. Synd4(-/-) mice were more susceptible to kappa-carrageenan-induced nephropathy, and the placental labyrinth from the deficient embryos exhibited more thrombi than wild-type ones. Importantly, Synd4(-/-) mice were more susceptible to endotoxin shock. Further analysis revealed that the mechanism to suppress excessive production of interieukin-1beta (1L-1beta) by transforming growth factor-beta (TGF-beta) was impaired in the deficient mice. TGF-beta, one of the cytokines involved in the suppression mechanism, bound to heparan sulfate chain of syndecan-4, which was induced in macrophages and the microvasculature after administration of lipopolysaccharide. Therefore, augmentation of TGF-beta function by induced syndecan-4 was suggested as a mechanism of the suppressive action of syndecan-4 against endotoxin shock.

引用

页码：315 / 318

页数：4

共 21 条

[1] INTERLEUKIN-10 IS A CENTRAL REGULATOR OF THE RESPONSE TO LPS IN MURINE MODELS OF ENDOTOXIC-SHOCK AND THE SHWARTZMAN REACTION BUT NOT ENDOTOXIN TOLERANCE [J].