Immune responses to DNA in normal and aberrant immunity

被引：18

作者：

Pisetsky, DS

机构：

[1] Duke Univ, Med Ctr, VA Med Ctr, Dept Med, Durham, NC 27705 USA

[2] Duke Univ, Med Ctr, VA Med Ctr, Dept Immunol, Durham, NC 27705 USA

来源：

IMMUNOLOGIC RESEARCH | 2000年 / 22卷 / 2-3期

关键词：

anti-DNA; autoimmunity; DNA; mitogenesis; immune activation; immune suppression; cytokines;

D O I：

10.1385/IR:22:2-3:119

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Because of structural microheterogeneity, DNA can exert powerful effects that lead to immune system activation as well as antibody induction. These activating effects resemble those of endotoxin and result from sequences that occur much more commonly in bacterial DNA than in mammalian DNA. In contrast, mammalian DNA can inhibit the response to bacterial DNA as well as other stimuli and may serve a counterregulatory role during infection. The recognition of the immune effects of DNA is relevant to the pathogenesis of a variety of infectious and inflammatory diseases including systemic lupus erythematosus, a prototypic autoimmune disease characterized by anti-DNA autoantibodies.

引用

收藏

页码：119 / 126

页数：8

相关论文

共 28 条

[1] ANTIBODIES TO DNA - A PERSPECTIVE [J].

EMLEN, W ;

PISETSKY, DS ;

TAYLOR, RP .

ARTHRITIS AND RHEUMATISM, 1986, 29 (12) :1417-1426

[2] INDUCTION OF CROSS-REACTIVE ANTI-DSDNA ANTIBODIES IN PREAUTOIMMUNE NZB/NZW MICE BY IMMUNIZATION WITH BACTERIAL-DNA [J].

GILKESON, GS ;

PIPPEN, AMM ;

PISETSKY, DS .

JOURNAL OF CLINICAL INVESTIGATION, 1995, 95 (03) :1398-1402

[3]

GILKESON GS, 1989, J IMMUNOL, V142, P1482

[4] THE ANTIBODY-RESPONSE OF NORMAL MICE TO IMMUNIZATION WITH SINGLE-STRANDED-DNA OF VARIOUS SPECIES ORIGIN [J].

GILKESON, GS ;

GRUDIER, JP ;

PISETSKY, DS .

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1989, 51 (03) :362-371

[5] CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation [J].

Häcker, H ;

Mischak, H ;

Miethke, T ;

Liptay, S ;

Schmid, R ;

Sparwasser, T ;

Heeg, K ;

Lipford, GB ;

Wagner, H .

EMBO JOURNAL, 1998, 17 (21) :6230-6240

[6] Bacterial DNA induces murine interferon-gamma production by stimulation of interleukin-12 and tumor necrosis factor-alpha [J].

Halpern, MD ;

Kurlander, RJ ;

Pisetsky, DS .

CELLULAR IMMUNOLOGY, 1996, 167 (01) :72-78

[7]

KAROUNOS DG, 1988, J IMMUNOL, V140, P451

[8] CpG motifs present in bacterial DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma [J].

Klinman, DM ;

Yi, AK ;

Beaucage, SL ;

Conover, J ;

Krieg, AM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (07) :2879-2883

[9] CPG MOTIFS IN BACTERIAL-DNA TRIGGER DIRECT B-CELL ACTIVATION [J].

KRIEG, AM ;

YI, AK ;

MATSON, S ;

WALDSCHMIDT, TJ ;

BISHOP, GA ;

TEASDALE, R ;

KORETZKY, GA ;

KLINMAN, DM .

NATURE, 1995, 374 (6522) :546-549

[10] Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs [J].

Krieg, AM ;

Wu, T ;

Weeratna, R ;

Efler, SM ;

Love-Homan, L ;

Yang, L ;

Yi, AK ;

Short, D ;

Davis, HL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (21) :12631-12636