Intestinal health benefits of bovine whey proteins after simulated gastrointestinal digestion

被引：42

作者：

Corrochano, Alberto R. ^{[1
,2
]}

Arranz, Elena ^{[1
]}

De Noni, Ivano ^{[3
]}

Stuknyte, Milda ^{[3
]}

Ferraretto, Anita ^{[4
]}

Kelly, Phil M. ^{[1
]}

Buckin, Vitaly ^{[2
]}

Giblin, Linda ^{[1
]}

机构：

[1] TEAGASC, Food Res Ctr, Moorepk, Fermoy P61 C996, Cork, Ireland

[2] Univ Coll Dublin, Sch Chem, Dublin D04 V1W8 4, Ireland

[3] Univ Milan, Dipartimento Sci Alimenti Nutr & Ambiente DeFENS, Via G Celoria 2, I-20133 Milan, Italy

[4] Univ Milan, LITA, Dipartimento Sci Biomed Salute, I-20090 Segrate, Italy

来源：

JOURNAL OF FUNCTIONAL FOODS | 2018年 / 49卷

关键词：

Whey protein; In vitro digestion; Bioactive peptide; Glucagon-like peptide-1; Dipeptidyl peptidase IV inhibitor; Antioxidant activity; INDUCED OXIDATIVE DAMAGE; IV INHIBITORY PEPTIDES; ANTIOXIDANT PEPTIDES; BIOACTIVE PEPTIDES; MILK-PROTEINS; DIPEPTIDYL; IDENTIFICATION; CONCENTRATE; LACTOFERRIN; RELEASE;

D O I：

10.1016/j.jff.2018.08.043

中图分类号：

TS2 [食品工业];

学科分类号：

100403 [营养与食品卫生学];

摘要：

Bovine whey proteins are widely incorporated in foods for their nutritional, health promoting and functional value. However, whey proteins are readily digested in the upper gut. The objective of this study was to determine the fate and bioactivity of bovine whey proteins post simulated gastrointestinal digestion (GID). Our results demonstrated that beta-lactoglobulin and alpha-lactalbumin post GID protect human intestinal cells from free radical formation. Post GID, lactoferrin significantly increased the amount of the intracellular antioxidant enzymes superoxide dismutase 1, 2 and thioredoxin. In addition, all whey samples post GID inhibited the activity of the dipeptidyl peptidase IV. However, the conditions of the gut destroyed the ability of whey proteins to act as glucagon-like peptide-1 secretagogues. The peptide profiles of GID whey protein isolate, beta-lactoglobulin, alpha-lactalbumin, bovine serum albumin and lactoferrin revealed several peptides with bioactive potential.

引用

页码：526 / 535

页数：10

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